• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Epigenetic alteration of Alzheimer disease candidate gene promoter region

Research Project

  • PDF
Project/Area Number 25893251
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionJikei University School of Medicine

Principal Investigator

NAGATA Tomoyuki  東京慈恵会医科大学, 医学部, 助教 (00408428)

Research Collaborator SHINAGAWA Shunichiro  東京慈恵会医科大学, 精神医学講座, 助教 (90459628)
KOBAYASHI Nobuyuki  東京慈恵会医科大学, ウイルス学講座, 助教 (20385321)
YAMADA Hisashi  東京慈恵会医科大学, 総合医科学研究所, 教授 (20130213)
NAKAYAMA Kazuhiko  東京慈恵会医科大学, 精神医学講座, 教授 (70155878)
Project Period (FY) 2013-08-30 – 2015-03-31
Keywordsアルツハイマー病 / エピジェティクス / 脳由来神経栄養因子 / DNAメチル化
Outline of Final Research Achievements

The methylation levels of brain-derived neurotrophic factor (BDNF) gene
promoter region was significantly higher in the Alzheimer disaese (AD) patients than in the Normal Controls (NCs). Moreover, the methylation level was significantly and negatively correlated with some neuropsychological test subscores (registration, recall, and prehension behaviors scores). Therefore, such result implies that BDNF gene methylation levels reflecting neurocognitive function in AD patients may be useful as a surrogate marker to predict the clinical presentations or prognosis.

Free Research Field

精神神経科

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi