Effect of night time shift work on the circadian clock system

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893265
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: TAHARA Yu 早稲田大学, 理工学術院, 助教 (80707399)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 体内時計 / 概日リズム / 交代勤務

Outline of Final Research Achievements

Nighttime shift work-induced chronic jet lag caused increased cancer incidence and metabolic disorder. However, the effect of shift work on the circadian clock in the peripheral tissues was not well understood, because of the absence of the appropriate model of shift work. In the present study, we developed new model of shift work by changing light-dark cycle with forced awake to mice. We found deceased amplitude of circadian oscillation in the peripheral tissues in this model, and also forced awake caused stress accumulation and circadian resetting in the peripheral clocks. In addition, we developed liver specific circadian clock monitoring method in vivo using AAV.

Free Research Field

時間生物学