2014 Fiscal Year Final Research Report
Prevention and treatment for sensorineural hearing loss by controlling the system of innate immunity
| Project/Area Number |
25893299
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
HAYASHI Yushi 独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 医師 (40715166)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Keywords | 蝸牛 / 自然免疫 / 有毛細胞 / 支持細胞 / 感音難聴 / ウイルス感染 / I型IFN / RIG-I family |
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| Outline of Final Research Achievements |
We analyzed the mechanism of sensorineural hearing loss caused by viral infection such as sudden hearing loss, Meniere's disease and congenital hearing loss using ex vivo system of cochlear sensory epithelia. To investigate the influence of type I interferon (IFN) which is transcribed in supporting cells during viral infection on the cochlear sensory epithelium, we used IFNAR1 which is a receptor of type I IFN knock out mice.
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| Free Research Field |
耳科学・内耳基礎・免疫学
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