Promotion of in vivo autologous tissue formation by light emitting diode: Application to development of Stent Biovalve

2014 Fiscal Year Final Research Report

• Project/Area Number: 25893303
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUNAYAMA Marina 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 研究員 (30713599)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Keywords: 心臓代替弁 / 肺動脈弁 / 心血管疾患

Outline of Final Research Achievements

Surgical valve replacement is an efficacious treatment for patients with cardiovascular disease, however the artificial heart valves have limitations regarding their durability. The in-body tissue architecture (IBTA) technology is a novel technique based on the tissue encapsulation phenomenon. Using this technology, autologous self-expanding valved stent, named Stent Biovalve, could be made simple and safe. However, the limited leaflet formation through the tissue migration was a serious problem. To solve this limitation, we have firstly established an effect on IBTA of the light radiation. Secondly, we evaluated directly and non-invasively the formation process of the leaflet tissues inside the mold. Moreover, we designed novel molds to activate leaflet formation. Finally, Stent Biovalve showed favorable hemodynamic results in pulmonary valve in beagles. Taken together, the novel method may improve a development of the functional Stent Biovalve.

Free Research Field

獣医学