2018 Fiscal Year Final Research Report
Signal transduction networks regulating life span and development
| Project/Area Number |
26221101
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Institute of Physical and Chemical Research (2018)
Kyoto University (2014-2017) |
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Principal Investigator |
Nishida Eisuke 国立研究開発法人理化学研究所, 生命機能科学研究センター, センター長 (60143369)
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| Project Period (FY) |
2014-05-30 – 2019-03-31
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| Keywords | 寿命 / 発生 / シグナル伝達 |
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| Outline of Final Research Achievements |
Using C. elegans, we identified molecular mechanisms underlying the transgenerational inheritance of acquired traits such as stress-induced longevity. We also identified several signaling pathways regulating diet restriction-induced longevity. Moreover, using Xenopus embryos, we identified signaling pathways regulating ciliated cell differentiation. Also, we developed a novel method for in vivo gene delivery into intestines of living mice, and found that the Hippo pathway regulates both stem cell proliferation and goblet cell differentiation in intestine epithelia.
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| Free Research Field |
生化学、細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
外因性ストレスによる寿命延長等の獲得形質の次世代への継承は、線虫のみならず動物一般の生存戦略のひとつである可能性が考えられ、そのメカニズムの解明は意義深い。また、ヒト生理機能にも必須となる繊毛細胞の発生に関与する、一連のシグナル伝達経路を明らかにすることができた。さらに、我々が開発したマウス腸上皮に遺伝子を導入する方法は、スイス連邦工科大学ローザンヌ校との共同研究に発展するなど、国際的な注目を集めた。
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