骨髄異形成症候群(MDS)の分子基盤の解明

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26221308
• Research Institution: Kyoto University
• Principal Investigator: 小川 誠司 京都大学, 医学研究科, 教授 (60292900)
• Co-Investigator(Kenkyū-buntansha): 古関 明彦 国立研究開発法人理化学研究所, 統合生命医科学研究センター, グループディレクター (40225446)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Keywords: 骨髄異形成症候群 / スプライシング因子 / コヘシン / クローン進化 / 二次性白血病

Outline of Annual Research Achievements

骨髄異形成症候群(MDS)は、骨髄不全と急性骨髄性白血病(AML)への移行を特徴とする、高齢者に多い慢性骨髄性腫瘍である。本研究では、近年の申請者らの研究成果(Yoshida et al., Nature. 2011)を踏まえ、RNAスプライシング因子の変異と、それらと共存する遺伝子変異が、どのようにしてMDSの発症を誘導し、白血病への進展が生ずるのかについて、世界トップレベルのゲノム解析技術を駆使した遺伝学的解析を通じて明らかにした。MDSにおける世界最大数204例の全エクソームシーケンス解析により、変異の数は、低リスクMDS期(一症例あたり6.4個)に比較し二次性AML期(12.7個)において、有意に増加していた(Makishima et al, Nat Genet. 2017)。続いて、病期進行に伴いどの遺伝子に異常が獲得されるのかについて検討するため、標的遺伝子シーケンスとしては、これまでの世界最大コホートである2,250例を解析した。高リスクMDS例から二次性AMLに進展する際に高頻度に獲得されるタイプ1異常（FLT3, PTPN11, WT1, IDH1, NPM1, IDH2, NRAS変異）と、低リスクMDSから高リスクMDSへ進行する際に獲得されるタイプ2異常（TP53, GATA2, KRAS, RUNX1, STAG2, ASXL1, ZRSR2, TET2変異）を明らかにした。タイプ1異常陽性の症例は、陰性の場合よりも白血病になりやすく早期に死亡し、タイプ2異常陽性の症例は、タイプ1が陽性の場合よりもインパクトは弱いものの他の異常よりも白血病になりやすいことが明らかにされた。以上の結果は今年度Nature Genetics誌へ掲載され、一定の成果が得られた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

MDSにおける集団内多様性とクローン進化の解析については、概ね予定どおり研究が進捗している状況である。集団内多様性の検討は、複数例にて検体を採取しエクソームシーケンスにて解析した。さらに、再生不良性貧血からMDSへのクローン進化の研究については、クローン進化について詳細に明らかにすることができ、今年度NEJM誌へ掲載され、予想以上の成果がえられたと考えている。
変異RNAスプライシング因子の遺伝子標的の同定についても200例以上のMDS患者試料および健常者コントロールの検体に関するRNAシーケンスの解析がほぼ終了した。最も頻度の高いスプライシング変異(U2AF1, SRSF2, SF3B1)においては、特徴的なスプライシング異常の解明と標的遺伝子が同定され、この点では予定通りの進捗が認められている。特にSF3B1変異においては病態と深く関わる遺伝子にスプライシング異常が検出され、大きな成果が得られたと考えている。
マウスモデルを用いた解析: MDSにおける主要な変異のうち、RNAスプライシング因子(sf3b1, srsf2, u2af1およびzrsr2)およびCohesin (smc3/stag2 cKO)、setbp1(cKOおよびD866N)に関してこれらの欠失アレルおよび機能獲得型アレルの構築を行い、B6系統への戻し交配がほぼ終了している。現在、setbp1およびzrsr2に関しては、造血細胞の形質を解析する準備を進めている。さらに研究が先行しているSrsf2 P95H変異体マウスについては、スプライシング異常を解析可能な状況となっており、全体として、おおむね順調に進捗しているものと考えられる。

Strategy for Future Research Activity

MDSにおける集団内多様性とクローン進化の解析:集団内多様性に関しては、さらに症例を追加して、現在のプレリミナリーな結果を検証する。クローン進化の解析に関しては、これまでのMDSへの進展時に生じる変異パターンの解析をうけて、MDSの進展および、二次性のAML発症のメカニズム解明を進める。初診時およびAML進展時に採取された試料、および、数年間にわたって経時的に採取されたMDS試料について標的シーケンスおよび全エクソンシーケンスを行う。さらに、これらのシーケンス結果の検証とデータ解析の結果を、実際の臨床経過に当てはめてモデル化を試みる。とりわけ、MDSからAMLへの進展にともなって生ずる遺伝子変異、および非白血病死に関係する因子の抽出をも試みる。
変異RNAスプライシング因子の遺伝子標的の同定 : これまでの解析から同定された標的遺伝子について、その異常がMDSの表現型、白血病進展を惹起するメカニズムについて、引き続き解析を行う。マウスモデル、ナンセンス依存性分解抑制など、機能解析技術を用いたシステムによって詳細な解析を行う。
マウスモデルを用いた解析: MDSにおける主要な変異である、RNAスプライシング因子およびCohesin、setbp1に関して戻し交配の進んだラインについては、順次解析を進める。具体的には、zrsr2およびsrsf2マウスについて重点的に解析を行う。srsf2変異マウスでは、srsf2変異単独ではMDSの表現型を示さないことから、SRSF2変異としばしば共存することが知られている他の変異との関連を検討することにより、両者の相互作用とそのMDS発症への役割について明らかにする。

Research Products

• [Journal Article] Dynamics of clonal evolution in myelodysplastic syndromes. (2017)
  • Author(s): Makishima H, et al.
  • Journal Title: Nat Genet. Volume: 49 Pages: 204-212
  • DOI: 10.1038/ng.3742
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Recurrent genetic defects on chromosome 5q in myeloid neoplasms. (2017)
  • Author(s): Hosono N, Makishima H, Mahfouz R, Przychodzen B, Yoshida K, Jerez A, LaFramboise T, Polprasert C, Clemente MJ, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Cui E, Verma AK, McDevitt MA, List AF, Saunthararajah Y, Sekeres MA, Boultwood J, Ogawa S, Maciejewski JP.
  • Journal Title: Oncotarget. Volume: 8 Pages: 6483-6495
  • DOI: 10.18632/oncotarget.14130
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities. (2017)
  • Author(s): Yoshida M, Hamanoue S, Seki M, Tanaka M, Yoshida K, Goto H, Ogawa S, Takita J, Tanaka Y.
  • Journal Title: Hum Pathol. Volume: - Pages: -
  • DOI: 10.1016/j.humpath.2016.06.024.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ASXL2 Mutations are Frequently Found in Pediatric AML Patients with t(8;21)/RUNX1-RUNX1T1 and Associated with a Better Prognosis. (2017)
  • Author(s): Yamato G, Shiba N, Yoshida K, Shiraishi Y, Hara Y, Ohki K, Okubo J, Okuno H, Chiba K, Tanaka H, Kinoshita A, Moritake H, Kiyokawa N, Tomizawa D, Park MJ, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Genes Chromosomes Cancer. Volume: - Pages: -
  • DOI: 10.1002/gcc.22443.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome. (2017)
  • Author(s): Takagi M, Ogata S, Ueno H, Yoshida K, Yeh T, Hoshino A, Piao J, Yamashita M, Nanya M, Okano T, Kajiwara M, Kanegane H, Muramatsu H, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Bando Y, Kato M, Hayashi Y, Miyano S, Imai K, Ogawa S, Kojima S, Morio T.
  • Journal Title: J Allergy Clin Immunol. Volume: - Pages: -
  • DOI: 10.1016/j.jaci.2016.09.038.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] BRCA1 Alterations with Additional Defects in DNA Damage Response Genes May Confer Chemoresistance to BRCA-like Breast Cancers Treated with Neoadjuvant Chemotherapy. (2017)
  • Author(s): Takada M, Nagai S, Haruta M, Sugino RP, Tozuka K, Takei H, Ohkubo F, Inoue K, Kurosumi M, Miyazaki M, Sato-Otsubo A, Sato Y, Ogawa S, Kaneko Y.
  • Journal Title: Genes Chromosomes Cancer. Volume: - Pages: -
  • DOI: 10.1002/gcc.22445
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). (2017)
  • Author(s): Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP.
  • Journal Title: Leukemia. Volume: 31 Pages: 1-10
  • DOI: 10.1038/leu.2016.160.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Partial monosomy of 10p and duplication of another chromosome in two patients. (2017)
  • Author(s): Ohta S, Isojima T, Mizuno Y, Kato M, Mimaki M, Seki M, Sato Y, Ogawa S, Takita J, Kitanaka S, Oka A.
  • Journal Title: Pediatr Int. Volume: 59 Pages: 99-102
  • DOI: 10.1111/ped.13181.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma. (2017)
  • Author(s): Nishizawa S, Sakata-Yanagimoto M, Hattori K, Muto H, Nguyen T, Izutsu K, Yoshida K, Ogawa S, Nakamura N, Chiba S.
  • Journal Title: Int J Hematol. Volume: - Pages: -
  • DOI: 10.1007/s12185-016-2159-z.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene. (2017)
  • Author(s): Nadeau SA, An W, Mohapatra BC, Mushtaq I, Bielecki TA, Luan H, Zutshi N, Ahmad G, Storck MD, Sanada M, Ogawa S, Band V, Band H.
  • Journal Title: J Biol Chem. Volume: - Pages: -
  • DOI: 10.1074/jbc.M116.772723.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. (2017)
  • Author(s): Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S.
  • Journal Title: Genet Med. Volume: - Pages: -
  • DOI: 10.1038/gim.2016.197.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia. (2017)
  • Author(s): Ikeda F, Yoshida K, Toki T, Uechi T, Ishida S, Nakajima Y, Sasahara Y, Okuno Y, Kanezaki R, Terui K, Kamio T, Kobayashi A, Fujita T, Sato-Otsubo A, Shiraishi Y, Tanaka H, Chiba K, Muramatsu H, Kanno H, Ohga S, Ohara A, Kojima S, Kenmochi N, Miyano S, Ogawa S, Ito E.
  • Journal Title: Haematologica. Volume: - Pages: -
  • DOI: 10.3324/haematol.2016.153932.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing. (2017)
  • Author(s): Ichimura T, Yoshida K, Okuno Y, Yujiri T, Nagai K, Nishi M, Shiraishi Y, Ueno H, Toki T, Chiba K, Tanaka H, Muramatsu H, Hara T, Kanno H, Kojima S, Miyano S, Ito E, Ogawa S, Ohga S.
  • Journal Title: Int J Hematol. Volume: - Pages: -
  • DOI: 10.3324/haematol.2016.153932.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. (2017)
  • Author(s): Hoshino A, Okada S, Yoshida K, Nishida N, Okuno Y, Ueno H, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Kobayashi M, Nakamura H, Kamizono J, Mitsui-Sekinaka K, Ichimura T, Ohga S, Nakazawa Y, Takagi M, Imai K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H.
  • Journal Title: J Allergy Clin Immunol. Volume: - Pages: -
  • DOI: 10.1016/j.jaci.2016.09.029.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia. (2017)
  • Author(s): Ding LW, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh Yeoh A, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernandez LT, Preethi H, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP.
  • Journal Title: Cancer Res. Volume: 77 Pages: 390-400
  • DOI: 10.1016/j.jaci.2016.09.029.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. (2017)
  • Author(s): Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, Alpermann T, Haferlach T, Yang H, Koeffler HP.
  • Journal Title: Leukemia. Volume: - Pages: -
  • DOI: 10.1038/leu.2016.343.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype. (2016)
  • Author(s): Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 457-461
  • DOI: 10.1111/bjh.14243.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Array CGH identifies copy number changes in 11% of 520 MDS patients with normal karyotype and uncovers prognostically relevant deletions. (2016)
  • Author(s): Volkert S, Haferlach T, Holzwarth J, Zenger M, Kern W, Staller M, Nagata Y, Yoshida K, Ogawa S, Schnittger S, Haferlach C.
  • Journal Title: Leukemia. Volume: 30 Pages: 259-261
  • DOI: 10.1038/leu.2015.257.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency. (2016)
  • Author(s): Tsujita Y, et al.
  • Journal Title: J Allergy Clin Immunol. Volume: 138 Pages: 1672-1680 e1610
  • DOI: 10.1016/j.jaci.2016.03.055.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Paroxysmal nocturnal hemoglobinuria induced by the occurrence of BCR-ABL in a PIGA mutant hematopoietic progenitor cell. (2016)
  • Author(s): Tominaga R, Katagiri T, Kataoka K, Kataoka K, Wee RK, Maeda A, Gomyo H, Mizuno I, Murayama T, Ogawa S, Nakao S.
  • Journal Title: Leukemia. Volume: 30 Pages: 1208-1210
  • DOI: 10.1038/leu.2015.268.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia. (2016)
  • Author(s): Shiba N, Yoshida K, Shiraishi Y, Okuno Y, Yamato G, Hara Y, Nagata Y, Chiba K, Tanaka H, Terui K, Kato M, Park MJ, Ohki K, Shimada A, Takita J, Tomizawa D, Kudo K, Arakawa H, Adachi S, Taga T, Tawa A, Ito E, Horibe K, Sanada M, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 476-489
  • DOI: 10.1111/bjh.14247.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele. (2016)
  • Author(s): Sakurai M, Kasahara H, Yoshida K, Yoshimi A, Kunimoto H, Watanabe N, Shiraishi Y, Chiba K, Tanaka H, Harada Y, Harada H, Kawakita T, Kurokawa M, Miyano S, Takahashi S, Ogawa S, Okamoto S, Nakajima H.
  • Journal Title: Blood Cancer J. Volume: 6 Pages: e392
  • DOI: 10.1038/bcj.2015.81.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of SNP array karyotyping on the diagnosis and the outcome of chronic myelomonocytic leukemia with low risk cytogenetic features or no metaphases. (2016)
  • Author(s): Palomo L, Xicoy B, Garcia O, Mallo M, Adema V, Cabezon M, Arnan M, Pomares H, Jose Larrayoz M, Jose Calasanz M, Maciejewski JP, Huang D, Shih LY, Ogawa S, Cervera J, Such E, Coll R, Grau J, Sole F, Zamora L.
  • Journal Title: Am J Hematol. Volume: 91 Pages: 185-192
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clonal hematopoiesis in acquired aplastic anemia. (2016)
  • Author(s): Ogawa S.
  • Journal Title: Blood. Volume: 128 Pages: 337-347
  • DOI: 10.1182/blood-2016-01-636381.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis. (2016)
  • Author(s): Niemoller C, Renz N, Bleul S, Blagitko-Dorfs N, Greil C, Yoshida K, Pfeifer D, Follo M, Duyster J, Claus R, Ogawa S, Lubbert M, Becker H.
  • Journal Title: Leuk Res. Volume: 47 Pages: 41-46
  • DOI: 10.1016/j.leukres.2016.05.008.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma. (2016)
  • Author(s): Nagata Y, et al.
  • Journal Title: Blood Volume: 127 Pages: 596-604
  • DOI: 10.1016/j.leukres.2016.05.008.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy. (2016)
  • Author(s): Muraoka M, Okuma C, Kanamitsu K, Ishida H, Kanazawa Y, Washio K, Seki M, Kato M, Takita J, Sato Y, Ogawa S, Tsukahara H, Oda M, Shimada A.
  • Journal Title: J Hum Genet. Volume: 61 Pages: 523-526
  • DOI: 10.1038/jhg.2016.8.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation. (2016)
  • Author(s): Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato-Otsubo A, Ogawa S, Shiina T, Satake M, Saji H, Kato S, Kodera Y, Sasazuki T, Morishima Y, Japan Marrow Donor P.
  • Journal Title: Haematologica. Volume: 101 Pages: 491-498
  • DOI: 10.3324/haematol.2015.136903.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms. (2016)
  • Author(s): Mori T, Nagata Y, Makishima H, Sanada M, Shiozawa Y, Kon A, Yoshizato T, Sato-Otsubo A, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Ishiyama K, Miyawaki S, Mori H, Nakamaki T, Kihara R, Kiyoi H, Koeffler HP, Shih LY, Miyano S, Naoe T, Haferlach C, Kern W, Haferlach T, Ogawa S, Yoshida K.
  • Journal Title: Leukemia. Volume: 30 Pages: 2270-2273
  • DOI: 10.1038/leu.2016.212.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Somatic mosaicism in chronic myeloid leukemia in remission. (2016)
  • Author(s): Mitani K, Nagata Y, Sasaki K, Yoshida K, Chiba K, Tanaka H, Shiraishi Y, Miyano S, Makishima H, Nakamura Y, Nakamura Y, Ichikawa M, Ogawa S.
  • Journal Title: Blood. Volume: 128 Pages: 2863-2866
  • DOI: 10.1182/blood-2016-06-723494
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents. (2016)
  • Author(s): Merlevede J, et al.
  • Journal Title: Nat Commun. Volume: 7 Pages: 10767
  • DOI: 10.1038/ncomms10767.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia. (2016)
  • Author(s): Maruyama H, Katagiri T, Kashiwase K, Shiina T, Sato-Otsubo A, Zaimoku Y, Maruyama K, Hosokawa K, Ishiyama K, Yamazaki H, Inoko H, Ogawa S, Nakao S.
  • Journal Title: Exp Hematol. Volume: 44 Pages: 931-939 e933
  • DOI: 10.1016/j.exphem.2016.05.013.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. (2016)
  • Author(s): Mansouri L, et al.
  • Journal Title: Blood. Volume: 128 Pages: 2666-2670
  • DOI: 10.1182/blood-2016-03-704528
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. (2016)
  • Author(s): Madan V, et al.
  • Journal Title: Leukemia. Volume: 30 Pages: 1672-1681
  • DOI: 10.1038/leu.2016.237.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional characterization of a novel GFI1B mutation causing congenital macrothrombocytopenia. (2016)
  • Author(s): Kitamura K, Okuno Y, Yoshida K, Sanada M, Shiraishi Y, Muramatsu H, Kobayashi R, Furukawa K, Miyano S, Kojima S, Ogawa S, Kunishima S.
  • Journal Title: J Thromb Haemost. Volume: 14 Pages: 1462-1469
  • DOI: 10.1038/leu.2016.237.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression. (2016)
  • Author(s): Kim T, Yoshida K, Kim YK, Tyndel MS, Park HJ, Choi SH, Ahn JS, Jung SH, Yang DH, Lee JJ, Kim HJ, Kong G, Ogawa S, Zhang Z, Kim HJ, Kim DD.
  • Journal Title: Leukemia. Volume: 30 Pages: 295-302
  • DOI: 10.1038/leu.2015.264.
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukaemia. (2016)
  • Author(s): Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa Y, Kishimoto H, Taki T, Akiyama M, Shiraishi Y, Chiba K, Tanaka H, Mitsuiki N, Kajiwara M, Mizutani S, Sanada M, Miyano S, Ogawa S, Koh K, Takita J.
  • Journal Title: Br J Haematol. Volume: 175 Pages: 169-172
  • DOI: 10.1111/bjh.13841.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. (2016)
  • Author(s): Kataoka K,et al.
  • Journal Title: Nature. Volume: 534 Pages: 402-406
  • DOI: 10.1111/bjh.13841.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Variegated RHOA mutations in human cancers. (2016)
  • Author(s): Kataoka K, Ogawa S.
  • Journal Title: Exp Hematol. Volume: 44 Pages: 1123-1129
  • DOI: 10.1016/j.exphem.2016.09.002.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia. (2016)
  • Author(s): Inaguma Y, Akatsuka Y, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A, Kuzushima K, Ogawa S, Emi N, Nakao S.
  • Journal Title: Br J Haematol. Volume: 172 Pages: 131-134
  • DOI: 10.1111/bjh.13464.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PIEZO1 gene mutation in a Japanese family with hereditary high phosphatidylcholine hemolytic anemia and hemochromatosis-induced diabetes mellitus. (2016)
  • Author(s): Imashuku S, Muramatsu H, Sugihara T, Okuno Y, Wang X, Yoshida K, Kato A, Kato K, Tatsumi Y, Hattori A, Kita S, Oe K, Sueyoshi A, Usui T, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Kanno H.
  • Journal Title: Int J Hematol. Volume: 104 Pages: 125-129
  • DOI: 10.1007/s12185-016-1970-x.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan. (2016)
  • Author(s): Ikeda F, Toki T, Kanezaki R, Terui K, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Ogawa S, Ito E.
  • Journal Title: Int J Hematol. Volume: 103 Pages: 112-114
  • DOI: 10.1007/s12185-015-1891-0.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. (2016)
  • Author(s): Arashiki N, Takakuwa Y, Mohandas N, Hale J, Yoshida K, Ogura H, Utsugisawa T, Ohga S, Miyano S, Ogawa S, Kojima S, Kanno H.
  • Journal Title: Haematologica. Volume: 101 Pages: 559-565
  • DOI: 10.3324/haematol.2016.142273.
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Genetic landscape of childhood acute myeloid leukemia (2016)
  • Author(s): Kenichi Yoshida
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川
  • Year and Date: 2016-12-15 – 2016-12-15
• [Presentation] Landscape of Driver Mutations and Their Clinical Impacts in Pediatric Acute Lymphoblastic Leukemia (2016)
  • Author(s): Hiroo Ueno, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
  • Int'l Joint Research
• [Presentation] The Impact of Clonal Dynamics on Prognosis and Outcome in Myelodysplastic Syndromes (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
  • Int'l Joint Research
• [Presentation] Whole-Genome Sequencing of Primary Central Nervous System Lymphoma and Diffuse Large B-Cell Lymphoma (2016)
  • Author(s): Kenichi Yoshidaet al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-05 – 2016-12-05
  • Int'l Joint Research
• [Presentation] Clinical significance of mutations and copy number lesions on prognosis of patients with MDS after unrelated bone marrow transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, et al.
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-03 – 2016-12-03
  • Int'l Joint Research
• [Presentation] Distinct genetic events in PNH and AA. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 58th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-12-02 – 2016-12-02
  • Int'l Joint Research
• [Presentation] がんにおけるクロマチン構造制御因子の異常 (2016)
  • Author(s): 吉田 健一
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30 – 2016-11-30
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida,et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Molecular profiling across different subtypes of B-cell lymphoma (2016)
  • Author(s): Yasunori Kogure, Keisuke Kataoka, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Tetsuichi Yoshizato, Yasunobu Nagata, Masashi Sanada, Motohiro Kato, Hiraku Mori, Yasuharu Sato, Tadashi Yoshino, Kengo Takeuchi, Yuichi Ishikawa, Satoru Miyano, Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Progress in diagnosis and therapy in myelodysplastic syndromes. (2016)
  • Author(s): Yasuhito Nannya
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-15 – 2016-10-15
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-14 – 2016-10-14
• [Presentation] The transcriptional and alternative splicing landscape of myelodysplastic syndromes (2016)
  • Author(s): Yusuke Shiozawa, Luca Malcovati, Anna Galli, Aiko Sato-Otsubo, Keisuke Kataoka, Yusuke Sato, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Eva Hellström Lindberg, Satoru Miyano, Mario Cazzola, and Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-14 – 2016-10-14
• [Presentation] Clinical Impact of Somatic Mutations on Clonal Evolution in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
  • Int'l Joint Research
• [Presentation] Biomarkers in AML. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] The biological characterization of Srsf2 P95H mutation in the pathogenesis of myelodysplasia (2016)
  • Author(s): Ayana Kon, Satoshi Yamazaki, Yusuke Shiozawa, Keisuke Kataoka, Yasunori Ota, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Kenichi Yoshida, Hideki Makisima, Yasuhito Nanya, Shinichi Kotani, June Takeda, Yosaku Watatani, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Landscape of driver mutations and its clinical significance in pediatric acute lymphoblastic leukemia (2016)
  • Author(s): Hiroo Ueno, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Prognostic Relevance of Integrated Molecular Profiling in Adult T-cell Leukemia/Lymphoma (2016)
  • Author(s): Yotaro Ochi, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Comparative mutational profiling of ATL and other PTCLs (2016)
  • Author(s): Yosaku Watatani, et al.
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Clonal evolution following azacitidine therapy in patients with high-risk myelodysplastic syndromes (2016)
  • Author(s): June Takeda, Kenichi Yoshida, Tetsuichi Yoshizato, Yusuke Shiozawa, Hideki Makishima, Yasuhito Nannya, Hiromichi Suzuki, Yuichi Shiraishi, Yusuke Okuno, Kenichi Chiba, Satoru Miyano, Masashi Sanada, Toru Kiguchi, Nobuaki Dobashi , Kensuke Usuki, Shigeru Chiba, Norio Asou, Yasuyuki Miyazaki, Tomoki Naoe, Hitoshi Kiyoi
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Landscape of MDS genomes as revealed by whole genome sequencing. (2016)
  • Author(s): Yasuhito Nannya, Kenichi Yoshida, Keisuke Kataoka, Yasunobu Nagata, Tetsuichi Yoshizato, Toru Kiguchi, Nobuaki Dobashi, Kensuke Usuki, Tomoki Naoe, Yukio Kobayashi, Hitoshi Kiyoi, Shigeru Chiba, Norio Aso, Yasushi Miyazaki, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 78th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-13 – 2016-10-13
• [Presentation] Clonal architecture in acquired aplastic anemia (2016)
  • Author(s): Tetsuichi Yoshizato,et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-08 – 2016-10-08
  • Int'l Joint Research
• [Presentation] Biological roles and potential therapeutic targeting of spliceosome mutations in myelodysplasia (2016)
  • Author(s): Ayana Kon, Seishi Ogawa
  • Organizer: The 75st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-08 – 2016-10-08
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida, Kenichi Chiba, Yusuke Okuno, Hiromichi Suzuki, Yuichi Shiraishi, Hiroko Tanaka, Yoshihiro Muragaki, Takashi Shiina, Satoru Miyano, Shigeru Chiba, Ryuya Yamanaka, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-07 – 2016-10-07
  • Int'l Joint Research
• [Presentation] Molecular profiling across different subtypes of B-cell lymphoma (2016)
  • Author(s): Yasunori Kogure, Keisuke Kataoka, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Motohiro Kato, Tadashi Yoshino, Kengo Takeuchi, Yuichi Ishikawa, Satoru Miyano, Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-07 – 2016-10-07
  • Int'l Joint Research
• [Presentation] Molecular basis of splicing factor-mutated myeloid neoplasms (2016)
  • Author(s): Yusuke Shiozawa, Luca Malcovati, Anna Galli, Aiko Sato-Otsubo, Keisuke Kataoka, Yusuke Sato, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Eva Hellström Lindberg, Satoru Miyano, Mario Cazzola, and Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-07 – 2016-10-07
  • Int'l Joint Research
• [Presentation] Clonal evolution following azacitidine therapy in patients with high-risk my elodysplastic syndromes (2016)
  • Author(s): 竹田 淳恵、吉田 健一、牧島 秀樹、白石 友一、千葉 健一、千葉 滋、麻生 範雄、宮﨑 泰司、直江 知樹、清井 仁、宮野
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-07 – 2016-10-07
  • Int'l Joint Research
• [Presentation] Prognostic relevance of integrated genetic profiling in pediatric acute lymphoblastic leukemia (2016)
  • Author(s): Hiroo Ueno, et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-06 – 2016-10-06
  • Int'l Joint Research
• [Presentation] Mutational Panel for Following Clonal Evolution in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, Tetsuichi Yoshizato, Kenichi Yoshida, Yasunobu Nagata, Mikkael Sekeres, Yusuke Okuno, Yuichi Shiraishi, Shigeru Chiba, Satoru Miyano, Lee-Yung Shih, Torsten Haferlach, Seishi Ogawa, Jaroslaw Maciejewski.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-06 – 2016-10-06
  • Int'l Joint Research
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-06 – 2016-10-06
  • Int'l Joint Research
• [Presentation] Prognostic Relevance of Integrated Molecular Profiling in Adult T-cell Leukemia/Lymphoma (2016)
  • Author(s): Yotaro Ochi, et al.
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-06 – 2016-10-06
  • Int'l Joint Research
• [Presentation] Landscape of MDS genomes as revealed by whole genome sequencing. (2016)
  • Author(s): Yasuhito Nannya, Kenichi Yoshida, Keisuke Kataoka, Yasunobu Nagata, Tetsuichi Yoshizato, Shigeru Chiba, Norio Aso, Yasushi Miyazaki, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2016-10-06 – 2016-10-06
  • Int'l Joint Research
• [Presentation] Prognostic Relevance of Integrated Molecular Profiling in Adult T-cell Leukemia/Lymphoma (2016)
  • Author(s): Yotaro Ochi, Keisuke Kataoka, Yasunobu Nagata, Akira Kitanaka, Jun-ichiro Yasunaga, Masako Iwanaga, Kisato Nosaka, Hidehiro Itonaga, Yositaka Imaizumi, Kotaro Shide, Yasushi Miyazaki, Akifumi Takaori-Kondo, Kazuya Shimoda, Masao Matsuoka, Toshiki Watanabe, Seishi Ogawa
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2016-08-27 – 2016-08-27
• [Presentation] ATLおよびT細胞リンパ腫における遺伝子変異プロファイルの解析 (2016)
  • Author(s): Yosaku Watatani, Yasuharu Sato, Kenji Nishida, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hiroo Ueno, Nobuyuki Kakiuchi, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Satoru Miyano, Koichi Ohshima, Tadashi Yoshino, Seishi Ogawa, Keisuke Kataoka
  • Organizer: 第3回日本HTLV-1学会学術集会
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2016-08-27 – 2016-08-27
• [Presentation] Clonal Dynamics in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The Japanese Society of Medical Oncology 2016 Annual Meeting
  • Place of Presentation: Kobe,Japan
  • Year and Date: 2016-07-29 – 2016-07-29
  • Invited
• [Presentation] Genetic landscape of primary central nervous system lymphoma (2016)
  • Author(s): Kenichi Yoshida, et al.
  • Organizer: The 21st Congress of European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-11 – 2016-06-11
  • Int'l Joint Research
• [Presentation] Dynamics of Clonal Evolution in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: 21st Congress European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-11 – 2016-06-11
  • Int'l Joint Research
• [Presentation] Impact of somatic mutations on outcome in patients with MDS after stem-cell transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: The 21st Congress of European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-10 – 2016-06-10
  • Int'l Joint Research
• [Presentation] GENETIC PREDISPOSITIONS TO SPORADIC MYELOID NEOPLASMS CAUSED BY GERMLINE DDX41 MUTATIONS IN ASIAN AND CAUCASIAN POPULATIONS. (2016)
  • Author(s): June Takeda, Kenichi Yoshida, Hideki Makishima, Tetsuichi Yoshizato, Yusuke Shiozawa, Hiromichi Suzuki, Yuichi Shiraishi, Yusuke Okuno, Ayana Kon, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Chantana Polprasert, Jaroslaw P. Maciejewski, and Seishi Ogawa
  • Organizer: The 21st Congress of European Hematology Association
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-10 – 2016-06-10
  • Int'l Joint Research
• [Presentation] Clinical and biological landscape of driver mutations in pediatric acute lymphoblastic leukemia (2016)
  • Author(s): Hiroo Ueno, Yuka Yamashita Kenichi Yoshida, Yusuke Shiozawa, Satomi Ishida, Hiroyuki Tsukamoto, Mayumi Kibe, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Takao Deguchi, Atsushi Sato, Yoshiko Hashii, Toshihiko Imamura, Satoru Miyano, Seishi Ogawa, Keizo Horibe, Masashi Sanada
  • Organizer: The 21st European Hematology Association congress
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-06-09 – 2016-06-09
  • Int'l Joint Research
• [Presentation] MDS Genomics and its Clincial Implication. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 5th National Conference on Hematologic Oncology
  • Place of Presentation: Nanjing,China
  • Year and Date: 2016-05-21 – 2016-05-21
  • Int'l Joint Research / Invited
• [Presentation] Impact of Somatic Mutations on Outcome in Patients with MDS after Stem-Cell Transplantation (2016)
  • Author(s): Tetsuichi Yoshizato, Yusuke Shiozawa, Kenichi Yoshida, Yoshiko Atsuta, Nannya Yasuhito, Hiromichi Suzuki, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kousuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, and Seishi Ogawa
  • Organizer: International Conference on Myelodysplastic Syndromes (ESH)
  • Place of Presentation: Estoril,Portugal
  • Year and Date: 2016-04-14 – 2016-04-14
  • Int'l Joint Research
• [Presentation] Clonal Dynamics in Myelodysplastic Syndromes. (2016)
  • Author(s): Hideki Makishima, et al.
  • Organizer: International Conference on Myelodysplastic Syndromes (ESH)
  • Place of Presentation: Estoril,Portugal
  • Year and Date: 2016-04-14 – 2016-04-14
  • Int'l Joint Research
• [Presentation] Cancer Genetics 4. (2016)
  • Author(s): Hideki Makishima
  • Organizer: The 13th International Congress of Human Genetics (ICHG2016)
  • Place of Presentation: 京都
  • Year and Date: 2016-04-07 – 2016-04-07
  • Int'l Joint Research