Molecular pathogenesis in myelodysplastic syndromes (MDS).

2018 Fiscal Year Annual Research Report

• Project/Area Number: 26221308
• Research Institution: Kyoto University
• Principal Investigator: 小川 誠司 京都大学, 医学研究科, 教授 (60292900)
• Co-Investigator(Kenkyū-buntansha): 古関 明彦 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (40225446)
• Project Period (FY): 2014-05-30 – 2019-03-31
• Keywords: 血液内科学 / 血液腫瘍学 / 骨髄異形成症候群

Outline of Annual Research Achievements

骨髄異形成症候群(MDS)およびその関連疾患は、骨髄不全と急性骨髄性白血病への進展を特徴とする、高齢者に好発する慢性骨髄性腫瘍である。MDSの主な死因である骨髄不全および急性白血病に関して、本研究課題において昨年度までに、全ゲノムおよびRNAシーケンスを含む世界トップレベルの遺伝子解析技術とマウスモデルを駆使した手法を用いて、多様な遺伝子変異がMDSを発症させ、MDSを白血病へ進展させるメカニズムについて明らかにした。本年度は、その成果に基づき、以上の解析結果を臨床情報と併せて解析することにより、予後を規定する遺伝子変異および発現異常の臨床的なインパクトを確認した。スプライス因子の変異に関しては、マウスモデルによる基礎的な機能解析を行い、変異マウスに特徴的なスプライス異常と、造血障害を確認した。さらに、コヘシン変異のマウスモデルに関しては、合併する変異とのマウスの交配を行い、詳細な機能解析を行った。その結果、コヘシン変異にRUNX1変異が合併することにより、コヘシン変異単独に比較して、DNAの三次元構造に著明な変化をみとめた。この三次元構造の変化は、付属するヒストン修飾蛋白の機能を変化させ、エピジェネティックな機序によりMDSから急性白血病への進展に関与する遺伝子発現に異常を起こし、臨床経過と関連することを明らかにした。この結果は学会発表をへて、現在論文化の予定である。このほか、最も予後が不良であることが知られているTP53変異陽性のMDSに関しても、その予後解析を詳細に行い、典型的な複雑核型をともなわないTP53変異陽性MDSの特徴について、国際共同研究を行い論文化し報告した。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Molecular pathogenesis of disease progression in MLL-rearranged AML (2019)
  • Author(s): Kotani S, Yoda A, Kon A, Kataoka K, Ochi Y, Shiozawa Y, Hirsch C, Takeda J, Ueno H, Yoshizato T, Yoshida K, Nakagawa MM, Nannya Y, Kakiuchi N, Yamauchi T, Aoki K, Shiraishi Y, Miyano S, Maeda T, Maciejewski JP, Takaori-Kondo A, Ogawa S, Makishima H
  • Journal Title: Leukemia Volume: 33 Pages: 612-624
  • DOI: 10.1038/s41375-018-0253-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis. (2019)
  • Author(s): Suma S, Sakata-Yanagimoto M, Nguyen TB, Hattori K, Sato T, Noguchi M, Nannya Y, Ogawa S, Watanabe R, Fujimoto M, Nakamura N, Kusakabe M, Nishikii H, Kato T, Chiba S."
  • Journal Title: Int J Hematol. Volume: 109 Pages: 309-318
  • DOI: 10.1007/s12185-018-02576-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. (2019)
  • Author(s): Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.
  • Journal Title: Haematologica. Volume: - Pages: -
  • DOI: 10.3324/haematol.2018.207241.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] KLF1 Mutation E325K Induces Cell-cycle Arrest in Erythroid Cells Differentiated from Congenital Dyserythropoietic Anemia (CDA) Patient-specific Induced Pluripotent Stem Cells. (2019)
  • Author(s): Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K.
  • Journal Title: Exp Hematol. Volume: 73 Pages: 25-37
  • DOI: 10.1016/j.exphem.2019.03.001.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Japan Adult Leukemia Study G. Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study. (2019)
  • Author(s): Kawashima N, Akashi A, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kitamura K, Sakaida E, Takeshita A, Suzushima H, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H,
  • Journal Title: Ann Hematol. Volume: 98 Pages: 83-91.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] International Working Group for MDSMPC. TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups. (2019)
  • Author(s): Haase D, Ogawa S.et al.,
  • Journal Title: Leukemia Volume: - Pages: -
  • DOI: 10.1038/s41375-018-0351-2.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation. (2019)
  • Author(s): Frick M, Ogawa S.et al.,
  • Journal Title: J Clin Oncol. Volume: 37 Pages: 375-385.
  • DOI: 10.1200/JCO.2018.79.2184.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia. (2019)
  • Author(s): Elbadry MI, Ogawa S.et al.,
  • Journal Title: Haematologica. Volume: - Pages: -
  • DOI: 10.3324/haematol.2018.210856.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): (2019)
  • Author(s): Christen F, Hoyer K, Yoshida K, Hou HA, Waldhueter N, Heuser M, Hills RK, Chan W, Hablesreiter R, Blau O, Ochi Y, Klement P, Chou WC, Blau IW, Tang JL, Zemojtel T, Shiraishi Y, Shiozawa Y, Thol F, Ganser A, Lowenberg B, Linch DC, Bullinger L, Valk PJM, Tien HF, Gale RE, Ogawa S, Damm F.
  • Journal Title: Blood. . Volume: 133 Pages: 1140-1151
  • DOI: 10.1182/blood-2018-05-852822.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia. (2019)
  • Author(s): Becker H, Greve G, Kataoka K, Mallm JP, Duque-Afonso J, Ma T, Niemoller C, Pantic M, Duyster J, Cleary ML, Schuler J, Rippe K, Ogawa S, Lubbert M.
  • Journal Title: Blood Adv. Volume: 3 Pages: 761-765.
  • DOI: 10.1182/bloodadvances.2018023879.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT (2018)
  • Author(s): Berger G, Kroeze LI, Koorenhof-Scheele TN, de Graaf AO, Yoshida K, Ueno H, Shiraishi Y, Miyano S, van den Berg E, Schepers H, van der Reijden BA, Ogawa S, Vellenga E, Jansen JH
  • Journal Title: Blood Volume: 131 Pages: 1846-1857
  • DOI: doi: 10.1182/blood-2017-09-805879
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia. (2018)
  • Author(s): Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, Suzuki K, Muto A, Fujiwara T, Nannya Y, Malcovati L, Cazzola M, Ogawa S, Harigae H, Igarashi K.
  • Journal Title: Nat Immunol Volume: 19 Pages: 1059-1070
  • DOI: 10.1038/s41590-018-0202-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia. (2018)
  • Author(s): Matsuo H, Ogawa S.et al.,
  • Journal Title: Blood Adv. Volume: 13 Pages: 2879-2889
  • DOI: 10.1182/bloodadvances.2018019398
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progression to polythythemia vera from familial thrombocytosis with germline JAK2 R867Q mutation. (2018)
  • Author(s): Maie K, Yokoyama Y, Yano Y, Kato T, Nannya Y, Ogawa S, Noguchi M, Sakata-Yanagimoto M, Chiba S.
  • Journal Title: Ann Hematol. Volume: 97 Pages: 737-739
  • DOI: 10.1007/s00277-017-3209-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of somatic mutations on the prognosis of myelodysplastic syndromes (2018)
  • Author(s): Yoshizato T
  • Journal Title: Rinsho Ketsueki Volume: 59 Pages: 1078-1085
  • DOI: 10.11406/rinketsu.59.1078
  • Peer Reviewed
• [Journal Article] Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia. (2018)
  • Author(s): Imi T, Katagiri T, Hosomichi K, Zaimoku Y, Hoang Nguyen V, Nakagawa N, Tajima A, Yoshizato T, Ogawa S, Nakao S.
  • Journal Title: Blood Adv. Volume: 2 Pages: 2
  • DOI: 10.1182/bloodadvances.2017013953.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Germline loss of function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes. (2018)
  • Author(s): Nagata Y, Narumi S, Guan Y, Przychodzen BP, Hirsch CM, Makishima H, Shima H, Aly M, Pastor V, Kuzmanovic T, Radivoyevitch T, Adema V, Awada H, Yoshida K, Li S, Sole F, Hanna R, Jha BK, LaFramboise T, Ogawa S, Sekeres MA, Wlodarski MW, Cammenga J, Maciejewski JP
  • Journal Title: Blood Volume: 132 Pages: 2309-2313
  • DOI: 10.1182/blood-2017-05-787390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia. (2018)
  • Author(s): Shiozawa Y, Malcovati L, Gall? A, Sato-Otsubo A, Kataoka K, Sato Y, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Makishima H, Shiraishi Y, Chiba K, Hellstrom-Lindberg E, Miyano S, Ogawa S, Cazzola M
  • Journal Title: Nat. Commun. Volume: 9 Pages: 3649
  • DOI: 10.1038/s41467-018-06063-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hidden FLT3-D835Y clone in FLT3-ITD-positive acute myeloid leukemia that evolved into very late relapse with T-lymphoblastic leukemia. (2018)
  • Author(s): Katagiri S, Umezu T, Azuma K, Asano M, Akahane D, Makishima H, Yoshida K, Watatani Y, Chiba K, Miyano S, Ogawa S, Ohyashiki JH, Ohyashiki K
  • Journal Title: Leuk Lymphoma Volume: 59 Pages: 1490-1493
  • DOI: 10.1080/10428194.2017.1382696
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. (2018)
  • Author(s): Molenaar RJ, Radivoyevitch T, Nagata Y, Khurshed M, Przychodzen B, Makishima H, Xu M, Bleeker FE, Wilmink JW, Carraway HE, Mukherjee S, Sekeres MA, van Noorden CJF, Maciejewski JP
  • Journal Title: Clin Cancer Res Volume: 24 Pages: 1705-1715
  • DOI: 10.1158/1078-0432.CCR-17-2796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria. (2018)
  • Author(s): Clemente MJ, Przychodzen B, Hirsch CM, Nagata Y, Bat T, Wlodarski MW, Radivoyevitch T, Makishima H, Maciejewski JP
  • Journal Title: Leukemia Volume: 32 Pages: 2507-2511
  • DOI: 10.1038/s41375-018-0138-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clonally related diffuse large B-cell lymphoma and interdigitating dendritic cell sarcoma sharing MYC translocation. (2018)
  • Author(s): Ochi Y, Hiramoto N, Yoshizato T, Ono Y, Takeda J, Shiozawa Y, Yoshida K, Kakiuchi N, Shiraishi Y, Tanaka H, Chiba K, Kazuma Y, Tabata S, Yonetani N, Uehara K, Yamashita D, Imai Y, Nagafuji K, Yamakawa M, Miyano S, Takaori-Kondo A, Ogawa S, Ishikawa T.
  • Journal Title: Haematologica Volume: 103 Pages: e553-e556
  • DOI: 10.3324/haematol.2018.193490.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences. (2018)
  • Author(s): Masaki S, Ikeda S, Hata A, Shiozawa Y, Kon A, Ogawa S, Suzuki K, Hakuno F, Takahashi SI, Kataoka N.
  • Journal Title: Front Genet. Volume: 10 Pages: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis. (2018)
  • Author(s): Yamato G, Shiba N, Yoshida K, Hara Y, Shiraishi Y, Ohki K, Okubo J, Park MJ, Sotomatsu M, Arakawa H, Kiyokawa N, Tomizawa D, Adachi S, Taga T, Horibe K, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Blood. Volume: 131 Pages: 2266-2270.
  • DOI: 10.1182/blood-2017-11-814442.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. (2018)
  • Author(s): Toki T, Ogawa S.et al.,
  • Journal Title: Am J Hum Genet. Volume: 103 Pages: 440-447
  • DOI: 10.1016/j.ajhg.2018.07.020.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Germline loss of function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes. (2018)
  • Author(s): Nagata Y, Narumi S, Guan Y, Przychodzen BP, Hirsch CM, Makishima H, Shima H, Aly M, Pastor V, Kuzmanovic T, Radivoyevitch T, Adema V, Awada H, Yoshida K, Li S, Sole F, Hanna R, Jha BK, LaFramboise T, Ogawa S, Sekeres MA, Wlodarski MW, Cammenga J, Maciejewski JP.
  • Journal Title: Blood. Volume: 6 Pages: 2309-2313
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrated molecular profiling of juvenile myelomonocytic leukemia. (2018)
  • Author(s): Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y, Muramatsu H.
  • Journal Title: Blood. Volume: 131 Pages: 1576-1586
  • DOI: 10.1182/blood-2017-07-798157
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evolutionary basis of HLA-DPB1 alleles affects acute GVHD in unrelated donor stem cell transplantation. (2018)
  • Author(s): Morishima S, Shiina T, Suzuki S, Ogawa S, Sato-Otsubo A, Kashiwase K, Azuma F, Yabe T, Satake M, Kato S, Kodera Y, Sasazuki T, Morishima Y, Japan Marrow Donor P.
  • Journal Title: Blood. Volume: 131 Pages: 808-817
  • DOI: 10.1182/blood-2017-08-801449.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia. (2018)
  • Author(s): Matsuo H, Ogawa S., et al.
  • Journal Title: Blood Adv. Volume: 2 Pages: 2879-2889
  • DOI: 10.1182/bloodadvances.2018019398.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism. (2018)
  • Author(s): Maruyama K, Aotsuka N, Kumano Y, Sato N, Kawashima N, Onda Y, Maruyama H, Katagiri T, Zaimoku Y, Nakagawa N, Hosomichi K, Ogawa S, Nakao S.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 24 Pages: 43-49
  • DOI: 10.1016/j.bbmt.2017.08.018.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion. (2018)
  • Author(s): Madan V, Han L, Hattori N, Teoh WW, Mayakonda A, Sun QY, Ding LW, Binte Mohd Nordin H, Lim SL, Shyamsunder P, Dakle P, Sundaresan J, Doan NB, Sanada M, Sato-Otsubo A, Meggendorfer M, Yang H, Said JW, Ogawa S, Haferlach T, Liang DC, Shih LY, Nakamaki T, Wang QT, Koeffler HP.
  • Journal Title: Haematologica. Volume: 103 Pages: 1980-1990
  • DOI: 10.3324/haematol.2018.189928.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sudden Intracranial Hemorrhage in a Patient With Atypical Chronic Myeloid Leukemia in Chronic Phase. (2018)
  • Author(s): Kouzuki K, Umeda K, Saida S, Kato I, Hiramatsu H, Funaki T, Kanda K, Muramatsu H, Yoshida K, Ogawa S, Adachi S.
  • Journal Title: J Pediatr Hematol Oncol. Volume: 40 Pages: e553-e556
  • DOI: 10.1097/MPH.0000000000001061
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia. (2018)
  • Author(s): Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, Suzuki K, Muto A, Fujiwara T, Nannya Y, Malcovati L, Cazzola M, Ogawa S, Harigae H, Igarashi K.
  • Journal Title: Nat Immunol. Volume: 19 Pages: 1059-1070
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hidden FLT3-D835Y clone in FLT3-ITD-positive acute myeloid leukemia that evolved into very late relapse with T-lymphoblastic leukemia. (2018)
  • Author(s): Katagiri S, Umezu T, Azuma K, Asano M, Akahane D, Makishima H, Yoshida K, Watatani Y, Chiba K, Miyano S, Ogawa S, Ohyashiki JH, Ohyashiki K.
  • Journal Title: Leuk Lymphoma. Volume: 59 Pages: 1490-1493
  • DOI: 10.1080/10428194.2017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. (2018)
  • Author(s): Kamijo R, Itonaga H, Kihara R, Nagata Y, Hata T, Asou N, Ohtake S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T, Kiyoi H, Miyazaki Y.
  • Journal Title: Leuk Res. Volume: 65 Pages: 34-41.
  • DOI: 10.1016/j.leukres.2017.12.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Donor cell-derived transient abnormal myelopoiesis as a specific complication of umbilical cord blood transplantation. (2018)
  • Author(s): Hiramoto N, Takeda J, Yoshida K, Ono Y, Yoshioka S, Yamauchi N, Fujimoto A, Maruoka H, Shiraishi Y, Tanaka H, Chiba K, Imai Y, Miyano S, Ogawa S, Ishikawa T.
  • Journal Title: Bone Marrow Transplant. Volume: 53 Pages: 225-227.
  • DOI: 10.1038/bmt.2017.226.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Japan Adult Leukemia Study Group J. Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. (2018)
  • Author(s): Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Onizuka M, Takeshita A, Ishida F, Suzushima H, Ishizawa K, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H,
  • Journal Title: Leuk Res. Volume: 66 Pages: 20-27
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia. (2018)
  • Author(s): Hamada M, Doisaki S, Okuno Y, Muramatsu H, Hama A, Kawashima N, Narita A, Nishio N, Yoshida K, Kanno H, Manabe A, Taga T, Takahashi Y, Miyano S, Ogawa S, Kojima S.
  • Journal Title: Int J Hematol. Volume: 108 Pages: 306-311
  • DOI: 10.1007/s12185-018-2482-7.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gain-of-function IKBKB mutation causes human combined immune deficiency. (2018)
  • Author(s): Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook MC.
  • Journal Title: J Exp Med. Volume: 215 Pages: 2715-2724
  • DOI: 10.1084/jem.20180639.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT. (2018)
  • Author(s): Berger G, Kroeze LI, Koorenhof-Scheele TN, de Graaf AO, Yoshida K, Ueno H, Shiraishi Y, Miyano S, van den Berg E, Schepers H, van der Reijden BA, Ogawa S, Vellenga E, Jansen JH.
  • Journal Title: Blood. Volume: 131 Pages: 1846-1857
  • Peer Reviewed
• [Journal Article] Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. (2018)
  • Author(s): Arends CM, Galan-Sousa J, Hoyer K, Chan W, Jager M, Yoshida K, Seemann R, Noerenberg D, Waldhueter N, Fleischer-Notter H, Christen F, Schmitt CA, Dorken B, Pelzer U, Sinn M, Zemojtel T, Ogawa S, Mardian S, Schreiber A, Kunitz A, Kruger U, Bullinger L, Mylonas E, Frick M, Damm F.
  • Journal Title: Leukemia. Volume: 131 Pages: 1846-1857
  • DOI: 10.1182/blood-2017-09-805879.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Clonal evolution in myelodysplastic syndrome (2018)
  • Author(s): Seishi Ogawa
  • Organizer: 6th TSH International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Somatic and Germline Mutations in Myelodysplastic Syndromes. (2018)
  • Author(s): Hideki Makishima
  • Organizer: The 6th TSH International Symposium.
  • Invited
• [Presentation] MOLECULAR PATHOGENESIS OF DISEASE PROGRESSION IN MLLREARRANGED AML (2018)
  • Author(s): Shinichi Kotani , Seishi Ogawa., et al.
  • Organizer: 23rd Congress of European Hematology Association (EHA)
  • Int'l Joint Research
• [Presentation] Stag2 regulates hematopoietic differentiation and self-renewal (2018)
  • Author(s): Yotaro Ochi, Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Kenichi Yoshida, Haruhiko Koseki, Manabu Nakayama, Akinori Yoda, Hideki Makishima, Akifumi Takaori-Kondo2, and Seishi Ogawa
  • Organizer: 23rd Congress of European Hematology Association (EHA)
  • Int'l Joint Research
• [Presentation] New targetes and biomarkers in hematological malignancies (2018)
  • Author(s): Seishi Ogawa
  • Organizer: 18th World Congress of Basic and Clinical Pharmacology
  • Int'l Joint Research / Invited
• [Presentation] Stag2 Regulates Hematopoietic Differentiation and Self-Renewal (2018)
  • Author(s): Seishi Ogawa
  • Organizer: The 9th JSH International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Sequential acquisition of mutations in myelodysplastic syndromes (2018)
  • Author(s): Hideki Makishima
  • Organizer: 41st IRCMS Seminar
  • Invited
• [Presentation] ゲノム医療の基盤づくり (2018)
  • Author(s): Seishi Ogawa
  • Organizer: 第７７回癌学会学術総会
  • Invited
• [Presentation] Mechanisms of the clonal evolution of MDS as revealed by single-cell sequencing. (2018)
  • Author(s): Masahiro M Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Zhao Lanying, June Takeda, Akinori Yoda, Ayana Kon, Tetsuichi Yoshizato, Hideki Makishima, and Seishi Ogawa
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Comprehensive analysis for genetic factors predictive of azacitidine treatment for MDS. (2018)
  • Author(s): Yasuhito Nannya, June Takeda, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Akifumi Takaori, Shigeru Chiba, Kazuma Ohyashiki, Yasushi Miyazaki, Tomoki Naoe, Satoru Miyano, Seishi Ogawa
  • Organizer: 77th Anulal Meeeting of the Japanese Cancer Association
• [Presentation] スプライシング因子変異による骨髄異形成症候群発症の分子病態の解明 (2018)
  • Author(s): Ayana Kon
  • Organizer: 77th Anulal Meeeting of the Japanese Cancer Association
• [Presentation] Functional analysis of DDX41 germline and somatic mutations in myeloid neoplasms. (2018)
  • Author(s): Ayana Kon, June Takeda, Keisuke Kataoka, Kenichi Yoshida, Masahiro Marshall Nakagawa, Tetsuichi Yoshizato, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
  • Organizer: 77th Anulal Meeeting of the Japanese Cancer Association
• [Presentation] ビッグデータ解析 (2018)
  • Author(s): Seishi Ogawa
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association
  • Invited
• [Presentation] Mechanisms of the clonal evolution of MDS as revealed by single-cell sequencing. (2018)
  • Author(s): Masahiro M Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Zhao Lanying, June Takeda, Akinori Yoda, Ayana Kon, Tetsuichi Yoshizato, Hisashi Tsurumi, Hideki Makishima, and Seishi Ogawa
  • Organizer: 第80回日本血液学会学術総会
• [Presentation] 高リスクMDSの新規治療について (2018)
  • Author(s): 南谷泰仁
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
  • Invited
• [Presentation] Comprehensive analysis for genetic factors predictive of azacitidine treatment for MDS. (2018)
  • Author(s): Yasuhito Nannya, Seishi Ogawa., et al.
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
• [Presentation] 再生不良性貧血とクローン性造血 (2018)
  • Author(s): 牧島秀樹
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
  • Invited
• [Presentation] Functional analysis of DDX41 germline and somatic mutations in myeloid neoplasms. (2018)
  • Author(s): Ayana Kon, June Takeda, Keisuke Kataoka, Kenichi Yoshida, Masahiro Marshall Nakagawa, Tetsuichi Yoshizato, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Seishi Ogawa
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
• [Presentation] 造血器腫瘍の治療におけるNGSパネルの利用 (2018)
  • Author(s): Seishi Ogawa
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
  • Invited
• [Presentation] Impact of genetic alterations in stem cell transplantation for myelodysplastic syndromes (2018)
  • Author(s): Tetsuichi Yoshizato
  • Organizer: The 80th Annual Meeting of the Japanese Society of Hematology
  • Int'l Joint Research
• [Presentation] Sequential acquisition of genetic mutations (2018)
  • Author(s): Hideki Makishima
  • Organizer: Annual Colloquium
• [Presentation] Analysis of clonal evolution/heterogeneity of MDS by simultaneous detection of both mutation and gene expression by single cell sequencing (2018)
  • Author(s): Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yutaka Kuroda, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Hisashi Tsurumi, Hideki Makishima, Shuichi Matsuda and Seishi Ogawa
  • Organizer: 60th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Genome-wide analysis of non-coding alterations in pan-myeloid cancers using whole genome sequencing. (2018)
  • Author(s): Yasuhito Nannya, Seishi Ogawa.,et al.
  • Organizer: 60th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Novel and Significant Impact of Germline Variants Predisposed to Pathogenic Somatic Mutations and Loss of Heterozygosity (LOH) in Myelodysplastic Syndromes (MDS) and Clonal Hematopoiesis of Indeterminate Potential (CHIP) (2018)
  • Author(s): Hideki_Makishima, Seishi Ogawa., et al.
  • Organizer: 60th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Invariant Patterns of Clonal Succession Determines Specific Phenotypic and Clinical Features of Myelodysplastic Syndromes (MDS) (2018)
  • Author(s): Yasunobu_Nagata,Seishi Ogawa,, et al.
  • Organizer: 60th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Opposing Pathogenesis of Germline_SAMD9/SAMD9L_Variants in Adult Myelodysplastic Syndrome (MDS) (2018)
  • Author(s): Yasunobu_Nagata,_Seishi Ogawa., et al.
  • Organizer: 60th American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Genomic Analysis of Myelodysplastic Syndromes Among Nagasaki Atomic Bomb Survivors (2018)
  • Author(s): Masataka_Taguchi,_Seishi Ogawa., et al.
  • Organizer: 61st American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Pan-Myeloid Leukemia Analysis: Machine Learning-Based Approach to Predict Phenotype and Clinical Outcomes Using Mutation Data (2018)
  • Author(s): Kiyomi_Morita,_Seishi Ogawa., et atl.
  • Organizer: 62nd American Society of Hematology Annual Meeting
  • Int'l Joint Research
• [Presentation] Clonal evolution of non-malignant proliferative lesions into breast cancers (2018)
  • Author(s): Tomomi Nishimura, Kenichi Yoshida, Yukiko Kawata, Yasuhide Takeuchi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Kosuke Aoki, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba, Yuichi Shiraishi, Kenichi Chiba, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, Seishi Ogawa
  • Organizer: San Antonio Breast Cancer Symposium 2018
  • Int'l Joint Research
• [Presentation] STAG2 mutations alter epigenic and transcriptional dynamics in myeloid neoplasms (2018)
  • Author(s): Ayana Kon
  • Organizer: Meeting of Leukemic and Hematopoietic Stem Cells in Tokyo
  • Invited
• [Presentation] On the Origin of Human Cancer (2018)
  • Author(s): Seishi Ogawa
  • Organizer: Institute for the Advanced Study of Human Biology (ASHBi)