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2016 Fiscal Year Annual Research Report

Development of risk assessment models for infectious diseases considering changes in climate, society and ecosystem

Research Project

Project/Area Number 26241025
Research InstitutionThe University of Tokyo

Principal Investigator

福士 謙介  東京大学, サステイナビリティ学連携研究機構, 教授 (30282114)

Co-Investigator(Kenkyū-buntansha) 渡部 徹  山形大学, 農学部, 教授 (10302192)
渡辺 幸三  愛媛大学, 理工学研究科(工学系), 准教授 (80634435)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords感染症 / リスク評価 / 途上国都市 / 洪水 / 気候変動 / 下痢症 / デング熱 / DALY
Outline of Annual Research Achievements

【タスク1:洪水起因の感染症リスクに関する定量的なモデルの構築】
アジアの途上国都市を想定し、気候変動や社会変動の影響を考慮した洪水起因の感染症リスクに関する定量的モデルを構築した。対象都市は最終的にはジャカルタ、メダン、スラバヤ、デンパサール、ハノイである。対象病原微生物はノロウイルスとし、指標微生物である大腸菌から類推した。気候変動予測に関して、RCPシナリオは4.5と8.5の2種類を解析した。GCMは当該地域に最も適合する物を選定し、2042年のアウトプットを行った。洪水時の行動を考えたQMRAを基本とし、家庭内における二次感染の影響を考慮したリスク評価モデルを構築し、ノロウイルス感染リスクを算出した。
【タスク2:健康リスクの保健経済学的分析のための指標開発】
東南アジア3ヵ国で実施したインタビュー調査から、洪水に頻発する感染症の種類およびそれに対する住民の感情を明らかにし、その結果を指標化した。この指標を用いて障害調整生存年(DALY)の算出手法を改良することで、洪水時の感染症による経済損失の評価を行った。
【タスク3:昆虫媒介感染症リスク評価のための疫学生態モデルの開発】
バンドンとマニラの2都市を対象に、気候パラメータに基づいてデング熱のリスク評価モデルを、機械学習アルゴリズムを用いて構築した。モデルは各都市全体のデング熱罹患率の時間変動(季節変動)と各都市内の局所地域の罹患率の空間変動の二つに着目してそれぞれ構築した。時間変動に関するモデルから、降雨イベントから2~4週間後と7~8週間後にそれぞれデング熱罹患率が高まる現象が明らかになった。さらに、南方振動指数により数カ月後のデング熱流行を中長期的に予測する高精度に予測できた。空間変動に関する評価では、都市内の洪水強度が高い地域や人が集まる機会が多い商業施設が多い地域で罹患率が高まる現象を高精度でモデル化できた。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

  • Research Products

    (28 results)

All 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] フエ大学(ベトナム)

    • Country Name
      VIET NAM
    • Counterpart Institution
      フエ大学
  • [Int'l Joint Research] パジャジャラン大学(インドネシア)

    • Country Name
      INDONESIA
    • Counterpart Institution
      パジャジャラン大学
  • [Int'l Joint Research] カンボジア工科大学(カンボジア)

    • Country Name
      CAMBODIA
    • Counterpart Institution
      カンボジア工科大学
  • [Int'l Joint Research] デラサール大学(フィリピン)

    • Country Name
      PHILIPPINES
    • Counterpart Institution
      デラサール大学
  • [Journal Article] Catchment Scale Modeling of Riverine Species Diversity Using Hydrological Simulation: Application to Tests of Species-Genetic Diversity Correlation2017

    • Author(s)
      Kei Nukazawa, So Kazama, and Kozo Watanabe
    • Journal Title

      Ecohydrology

      Volume: 10 Pages: e1778

    • DOI

      10.1002/eco.1778

    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative Tests of Species-Genetic Diversity Correlations in Neutral and Non-neutral Loci in Four Species of Stream Insect2017

    • Author(s)
      Kozo Watanabe and Michael T Monaghan
    • Journal Title

      Evolution

      Volume: in press Pages: in press

    • DOI

      10.1111/evo.13261

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New species and records of Leuctridae (Plecoptera) from Guangxi, China, on the basis of morphological and molecular data, with emphasis on Rhopalopsole2017

    • Author(s)
      Weihai Li, David Muranyi, Maribet Gamboa, Ding Yang, and Kozo Watanabe
    • Journal Title

      Zootaxa

      Volume: 4243(1) Pages: 165-176

    • DOI

      http://dx.doi.org/10.11646/zootaxa.4243.1.8

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative Assessment of Primary and Secondary Infection Risks in a Norovirus Outbreak Using a Household Model Simulation2016

    • Author(s)
      Fuminari Miura, Toru Watanabe, Kozo Watanabe, Kazuhiko Takemoto, and Kensuke Fukushi
    • Journal Title

      Journal of Environmental Sciences

      Volume: 50 Pages: 13-20

    • DOI

      https://doi.org/10.1016/j.jes.2016.05.041

    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spatial Analysis of Wing Geometry in Dengue Vector Mosquito, Aedes aegypti (L.) (Diptera; Culicidae) Populations in Metropolitan Manila, Philippines2016

    • Author(s)
      Thaddeus M. Carvajal, Lara Fides T. Hernandez, Howell T. Ho, Menard G. Cuenca, Bianca Marie C. Orantia, Camille R. Estrada, Divina M. Amalin, and Kozo Watanabe
    • Journal Title

      Journal of Vector Borne Diseases

      Volume: 53(2) Pages: 127-135

    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of Outlier Loci Responding to Anthropogenic and Natural Selection Pressure in Stream Insects Based on a Self-Organizing Map2016

    • Author(s)
      Bin Li, Kozo Watanabe, Dong-Hwan Kim, Sang-Bin Lee, Muyoung Heo, Heui-Soo Kim and Tae-Soo Chon
    • Journal Title

      Water

      Volume: 8(5) Pages: 188

    • DOI

      10.3390/w8050188

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Genes Coding for Histone H3, 18S rRNA, and Cytochrome oxidase subunit I of East Asian Mayflies (Ephemeroptera)2016

    • Author(s)
      Kei Wakimura, Yasuhiro Takemon, Atsushi Takayanagi, Shin-ichi Ishiwata, Kozo Watanabe, Kazumi Tanida, Nobuyoshi Shimizu, and Mikio Kato
    • Journal Title

      DNA Barcodes

      Volume: 4 Pages: 1-25

    • Peer Reviewed
  • [Journal Article] 次世代シーケンス解析による瀬切れ河川の水生昆虫複数種を対象とした流域内交流パターンの網羅的評価2016

    • Author(s)
      八重樫咲子,泉昴佑,三宅洋,渡辺幸三
    • Journal Title

      土木学会論文集G(環境)

      Volume: 72(7) Pages: III_489-III_496

    • DOI

      http://doi.org/10.2208/jscejer.72.III_489

    • Peer Reviewed
  • [Journal Article] メタバーコーディングを活用した排砂バイパスダム上下流間の河川底生動物の群集構造の評価2016

    • Author(s)
      渡辺幸三,近藤俊介,泉昂佑,八重樫咲子
    • Journal Title

      土木学会論文集G(環境)

      Volume: 72(7) Pages: III_559-III_566

    • DOI

      http://doi.org/10.2208/jscejer.72.III_559

    • Peer Reviewed
  • [Presentation] The Correlation of Urban Climate and Dengue: Metro Manila and Bandung Cases2017

    • Author(s)
      Kozo Watanabe, Thaddeus M. Carvajal, Lia Faridah, Dwi Agustian, Nurrachman, Fedri Rinawan, Howell T. Ho, Divina Amalin, Chiho Watanabe
    • Organizer
      The Japan Geoscience Union (JpGU) and the American Geophysical Union (AGU) joint meeting
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2017-05-20 – 2017-05-25
    • Int'l Joint Research
  • [Presentation] Time series analysis of seasonal correlation between concentration of norovirus in sewage and clinical cases of acute gastroenteritis2017

    • Author(s)
      Fuminari Miura, Toru Watanabe, Kozo Watanabe, Kensuke Fukushi
    • Organizer
      19th International Symposium on Health-Related Water Microbiology
    • Place of Presentation
      UNC Chapel Hill (Chapel Hill, NC, USA)
    • Year and Date
      2017-05-15 – 2017-05-19
    • Int'l Joint Research
  • [Presentation] 流出解析を利用した河川無脊椎生物の生息分布予測モデルの開発2017

    • Author(s)
      糠澤桂,風間聡,渡辺幸三
    • Organizer
      第51回日本水環境学会年会
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Year and Date
      2017-03-15 – 2017-03-17
  • [Presentation] Eco-epidemiology of Dengue Mosquitoes in the Philippines: Modeling and Genetic Approaches2017

    • Author(s)
      Kozo Watanabe
    • Organizer
      9th Scientific Meeting of the Philippine Society for Parasitology
    • Place of Presentation
      Manila, Philippines
    • Year and Date
      2017-03-10 – 2017-03-10
    • Int'l Joint Research / Invited
  • [Presentation] Presence of Wolbachia sp in Culex sp. from Metro Manila, Philippines2017

    • Author(s)
      Kristin Joyce Go, Kazuki Hashimoto, Angel Judan Cruz, Thaddeus M. Carvajal, Monique Martinez, Jayson Capistrano, Vincent Stefano, Divina Amalin and Kozo Watanabe
    • Organizer
      9th Scientific Meeting of the Philippine Society for Parasitology
    • Place of Presentation
      Manila, Philippines
    • Year and Date
      2017-03-10 – 2017-03-10
    • Int'l Joint Research
  • [Presentation] Dengue risk modeling in Metro Manila, Philippines using land use and climate variables2017

    • Author(s)
      Thaddeus M. Carvajal,, Yoshiki Kubo, Katherine M. Viacrusis, Lara Fides T., Hernandez, Howell T. Ho, Divina Amalin, and Kozo Watanabe
    • Organizer
      2nd International Forum on Sustainable Future in Asia
    • Place of Presentation
      Udayana University (Bali, Indonesia)
    • Year and Date
      2017-01-26 – 2017-01-28
  • [Presentation] One-year monitoring of oyster contamination with human norovirus in a lagoon affected by urban drainage in Vietnam2016

    • Author(s)
      Gia Thanh Nguyen, Hiroaki Ito, Jian Pu, Le Van An, Toru Watanabe
    • Organizer
      12th International Symposium on Southeast Asian Water Environment
    • Place of Presentation
      Melia Hanoi (Hanoi, Vietnam)
    • Year and Date
      2016-11-28 – 2016-11-30
    • Int'l Joint Research
  • [Presentation] Dengue risk modeling in Metro Manila, Philippines using land use and climate variables2016

    • Author(s)
      Thaddeus M. Carvajal, Yoshiki Kubo, Katherine M. Viacrusis, Lara Fides T. Hernandez, Howell T. Ho, Divina Amalin, and Kozo Watanabe
    • Organizer
      第57回日本熱帯医学会大会
    • Place of Presentation
      一橋大学(東京都千代田区)
    • Year and Date
      2016-11-05 – 2016-11-06
  • [Presentation] Detection of dengue viruses in individual Aedes aegypti mosquitoes during the 2015 dengue outbreak in Tarlac City, Philippines2016

    • Author(s)
      Jean Claude Balingit, Thaddeus Carvajal, Mariko Saito-Obata, Maribet Gamboa, Hitoshi Oshitani, Kozo Watanabe
    • Organizer
      第57回日本熱帯医学会大会
    • Place of Presentation
      一橋大学(東京都千代田区)
    • Year and Date
      2016-11-05 – 2016-11-06
  • [Presentation] Fine-spatial genetic analysis of dengue vector, Aedes aegypti, in Metropolitan Manila, Philippines2016

    • Author(s)
      Thaddeus M. Carvajal, Kohei Ogishi, Sakiko Yaegeshi, Lara Fides T. Hernandez, Katherine M. Viacrusis Howell T. Ho, Divina Amalin, and Kozo Watanabe
    • Organizer
      第57回日本熱帯医学会大会
    • Place of Presentation
      一橋大学(東京都千代田区)
    • Year and Date
      2016-11-05 – 2016-11-06
  • [Presentation] Modified disability weights for diarrhea diseases based on feeling of flood-affected people in Asian developing countries2016

    • Author(s)
      Gia Thanh Nguyen, Yuri Kanaya, Jian Pu, Toru Watanabe
    • Organizer
      Water and Environment Technology Conference (WET2016)
    • Place of Presentation
      中央大学(東京都千代田区)
    • Year and Date
      2016-09-27 – 2016-09-28
    • Int'l Joint Research
  • [Presentation] PRESENCE OF Wolbachia sp. IN MOSQUITO SPECIES OF METRO MANILA, PHILIPPINES2016

    • Author(s)
      Thaddeus M. Carvajal, Kristin Joyce D. Go, Monique Martinez, Jayson Capistrano, Vincent Stefano, Divina Amalin and Kozo Watanabe
    • Organizer
      XXV International Congress of Entomology
    • Place of Presentation
      Orange County Convention Center (Orlando, FL, USA)
    • Year and Date
      2016-09-25 – 2016-09-30
    • Int'l Joint Research
  • [Presentation] Adaptive genetic consequences of climate change for stream insects: a hydrothermal simulation approach2016

    • Author(s)
      Nukazawa, K., Kazama, S., Watanabe, K.
    • Organizer
      20th Congress of the Asia and Pacific Division of the International Association for Hydro-Environment Engineering and Research (IAHR-APD)
    • Place of Presentation
      Galadari Hotel (Colombo, Sri Lanka)
    • Year and Date
      2016-08-28 – 2016-08-31
    • Int'l Joint Research
  • [Funded Workshop] 2nd International Forum on Sustainable Future in Asia2017

    • Place of Presentation
      Udayana University (Bali, Indonesia)
    • Year and Date
      2017-01-27 – 2017-01-27
  • [Funded Workshop] Dengue and Urban Climate Symposium2016

    • Place of Presentation
      De La Salle University (Manila,Philippines)
    • Year and Date
      2016-07-07 – 2016-07-07

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Published: 2018-01-16  

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