2016 Fiscal Year Final Research Report

Development of analysis method of accurate mass data for monitoring chemicals in environment

Research Project

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Project/Area Number	26241026
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Environmental risk control and evaluation
Research Institution	National Institute for Environmental Studies
Principal Investigator	HASHIMOTO Shunji 国立研究開発法人国立環境研究所, 環境計測研究センター, 室長 (80321719)
Co-Investigator(Kenkyū-buntansha)	大塚宜寿埼玉県環境科学国際センター, 化学物質担当, 研究員 (30415393) 山本敦史大阪市立環境科学研究所, 調査研究課, 研究員 (40332449) 高澤嘉一国立研究開発法人国立環境研究所, 環境計測研究センター, 主任研究員 (40391122) 柏木宣久統計数理研究所, 大学共同利用機関等の部局等, 教授 (50150032) 田邊潔国立研究開発法人国立環境研究所, 環境計測研究センター, フェロー (60150174) 頭士泰之国立研究開発法人産業技術総合研究所, 排出暴露解析グループ, 研究員 (80611780)
Co-Investigator(Renkei-kenkyūsha)	ANAZAKI Katsunori 北海道立総合研究機構, 環境・地質研究本部・環境科学研究センター・環境保全部, 研究主任 (20442634) OOHARA Toshihiko 広島県立総合技術研究所, 保健環境センター・環境研究部, 研究部長 (20419930)
Research Collaborator	HANNO Katsumasa 千葉県環境研究センター, 水質環境研究室, 室長
Project Period (FY)	2014-04-01 – 2017-03-31
Keywords	環境モニタリング / 精密質量 / ノンターゲット分析 / 網羅分析 / 迅速分析 / 未知物質 / インフォマティクス
Outline of Final Research Achievements	Air or water samples collected onto solid phase sampler were directly introduced into an instrument by thermal desorption due to achieve rapid and non-targeted analysis. A comprehensive gas chromatography-high resolution time-of-flight mass spectrometry (GC×GC-HRToFMS) was effective for precious separation of huge number of chemicals in samples. Exact mass measurement made it possible to select chemicals by post data processing such as mass defect filtration that was especially effective to remove hydrocarbons from a data. And reliable estimation of unknown chemicals required above 30,000 of mass resolution. Non-negative matrix factorization (NMF) was applied to detection of data difference and compensation method of retention times of each two-dimensional chromatograms from GC×GC-HRToFMS, which was essential to data comparison, was also developed in this study. Consequently, rapid and informative non-targeted environmental monitoring method was developed based on GC-HRTofMS.
Free Research Field	環境リスク、環境分析