Neural control mechanisms during gaze and posture in health and disease

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26242041
• Research Institution: Osaka University
• Principal Investigator: 野村 泰伸 大阪大学, 基礎工学研究科, 教授 (50283734)
• Co-Investigator(Kenkyū-buntansha): 佐古田 三郎 独立行政法人国立病院機構 刀根山病院(臨床研究部), 独立行政法人国立病院機構刀根山病院, 病院長 (00178625) ; 清野 健 大阪大学, 基礎工学研究科, 准教授 (40434071) ; 小林 康 大阪大学, 生命機能研究科, 准教授 (60311198) ; 望月 秀樹 大阪大学, 医学系研究科, 教授 (90230044)
• Project Period (FY): 2014-06-27 – 2017-03-31
• Keywords: 生体医工学 / 生体生命情報学 / 生体シミュレーション / 生体運動制御 / 計算論的神経科学 / パーキンソン病 / 姿勢制御 / 非線形システム

Outline of Annual Research Achievements

本研究は、直立静止立位姿勢および固視時の眼球姿勢を、姿勢の柔軟性を保ちながらもロバストに安定する神経制御に関する理論を構築すること、より具体的に言えば、身体（四肢・体幹）や眼球の姿勢を安定化する間欠制御理論を構築し、その生理的妥当性を示すこと、および、こうした姿勢機能が破綻する神経症候（運動障害）を発生メカニズムを明らかにすることであった。最終年度であるH28年度は、主として以下の２つの課題を実施した。（１）ヒト静止立位時の姿勢動揺に見られる足関節と股関節の協調運動の発現メカニズムを実験的・理論的に検討し、それが我々が提唱する間欠制御仮説でよく説明できることを明らかにした。また、足・股関節間の協調運動が増幅されるような立位環境を実験的に構築し、その際の協調運動および脳活動（脳波）の計測し、協調運動の生成に関わるような脳活動の同定にある程度の目処を立てることができた。（２）固視微動（眼球姿勢のゆらぎ）を計測し、そこに現れる新規で大変興味深い動特性を発見することができた（未発表）。こうして得られた特性に基づき、眼球姿勢維持の神経制御メカニズムに関する全く新しい仮説（理論）を構築することができた（未発表）。現在この仮説の妥当性の最終的な検証を進めると共に、論文公開の準備を進めているところである。これらの成果に加え、ヒト二足歩行の間欠制御モデルにおいて、制御の安定性を改善する新規モデルの構築も実施できた。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Italian Institute of Technology(Italy)
  • Country Name: Italy
  • Counterpart Institution: Italian Institute of Technology
• [Journal Article] Dynamic determinants of the uncontrolled manifold during human quiet stance (2016)
  • Author(s): Yasuyuki Suzuki, Hiroki Morimoto, Ken Kiyono, Pietro G Morasso, Taishin Nomura
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 618
  • DOI: 10.3389/fnhum.2016.00618
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reinforcement learning for stabilizing an inverted pendulum naturally leads to intermittent feedback control as in human quiet standing (2016)
  • Author(s): Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
  • Journal Title: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016 Volume: - Pages: 37-40
  • DOI: 10.1109/EMBC.2016.7590634
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Postural flexibility during quiet standing in healthy elderly and patients with Parkinson's disease (2016)
  • Author(s): Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura
  • Journal Title: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016 Volume: - Pages: 29-32
  • DOI: 10.1109/EMBC.2016.7590632
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The brain can mix different control strategies in a task-oriented and multi-referential manner: A simulation study (2016)
  • Author(s): Pietro Morasso, Taishin Nomura, Yasuyuki Suzuki, Jacopo Zenzeri
  • Journal Title: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2016 Volume: - Pages: 9-12
  • DOI: 10.1109/EMBC.2016.7590627
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The pedunculopontine tegmental nucleus as a motor and cognitive interface between the cerebellum and basal ganglia (2016)
  • Author(s): Fumika Mori, Ken-ichi Okada, Taishin Nomura, Yasushi Kobayashi
  • Journal Title: Frontiers in Neuroanatomy Volume: 10 Pages: 109
  • DOI: 10.3389/fnana.2016.00109
  • Peer Reviewed / Open Access
• [Journal Article] Intermittent feedback-control strategy for stabilizing inverted pendulum on manually controlled cart as analogy to human stick balancing (2016)
  • Author(s): Naoya Yoshikawa, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
  • Journal Title: Frontiers in computational neuroscience Volume: 10 Pages: 3389
  • DOI: 10.3389/fncom.2016.00034
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Stability and Flexibility During Human Motor Control (2016)
  • Author(s): Taishin Nomura, Yasuyuki Suzuki, Chunjiang Fu, Naoya Yoshikawa, Ken Kiyono, Maura Casadio, Pietro Morasso
  • Journal Title: Advances in Cognitive Neurodynamics (V) Volume: 5 Pages: 67-73
  • DOI: 10.1007/978-981-10-0207-6_11
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Model of Gait Cycle Variability During Human Walking (2016)
  • Author(s): Chunjiang Fu, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
  • Journal Title: Advances in Cognitive Neurodynamics (V) Volume: 5 Pages: 79084
  • DOI: 10.1007/978-981-10-0207-6_13
  • Peer Reviewed / Int'l Joint Research
• [Presentation] ヒト立位姿勢・歩行・スティックバランス制御系の運動揺らぎに見られる臨界的挙動の数理モデル化 (2016)
  • Author(s): 野村泰伸
  • Organizer: 計測自動制御学会ライフエンジニアリング部門シンポジウム2016
  • Place of Presentation: 大阪国際交流センター（大阪府・大阪市）
  • Year and Date: 2016-11-03 – 2016-11-05
• [Presentation] An intermittent feedback controller for stabilizing human upright posture can be acquired through reinforcement learning (2016)
  • Author(s): Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
  • Organizer: 計測自動制御学会ライフエンジニアリング部門シンポジウム2016
  • Place of Presentation: 大阪国際交流センター（大阪府・大阪市）
  • Year and Date: 2016-11-03 – 2016-11-05
• [Presentation] Intermittency and loss of intermittency during human motor control in health and disease (2016)
  • Author(s): Taishin Nomura, Yasuyuki Suzuki, Fu Chunjiang, Ken Kiyono
  • Organizer: 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: 大阪国際交流センター（大阪府・大阪市）
  • Year and Date: 2016-11-01 – 2016-11-05
  • Int'l Joint Research
• [Presentation] Skin motion artifact in motion capturing of human bipedal gait: Characterization and influence on joint torque estimation (2016)
  • Author(s): Takuya Inoue, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
  • Organizer: 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: 大阪国際交流センター（大阪府・大阪市）
  • Year and Date: 2016-11-01 – 2016-11-03
  • Int'l Joint Research
• [Presentation] A novel characterization of fixational eye movements (2016)
  • Author(s): Hajime Tanaka, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
  • Organizer: 生体医工学シンポジウム2016
  • Place of Presentation: 旭川市大雪クリスタルホール国際会議場（北海道・旭川市）
  • Year and Date: 2016-09-17 – 2016-09-18
• [Presentation] Reinforcement learning for stabilizing an inverted pendulum naturally leads to intermittent feedback control as in human quiet standing (2016)
  • Author(s): Kenjiro Michimoto, Yasuyuki Suzuki, Ken Kiyono, Yasushi Kobayashi, Pietro Morasso, Taishin Nomura
  • Organizer: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
  • Place of Presentation: Disney's Contemporary Resort (Orlando, USA)
  • Year and Date: 2016-08-16 – 2016-08-20
  • Int'l Joint Research
• [Presentation] Postural flexibility during quiet standing in healthy elderly and patients with Parkinson's disease (2016)
  • Author(s): Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura
  • Organizer: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
  • Place of Presentation: Disney's Contemporary Resort (Orlando, USA)
  • Year and Date: 2016-08-16 – 2016-08-20
  • Int'l Joint Research
• [Funded Workshop] 8th International Workshop on Biosignal Interpretation (2016)
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2016-11-01 – 2016-11-03