Pulse glucometry: Pioneering research towards practical non-invasive optical measurement of blood glucose

2017 Fiscal Year Final Research Report

• Project/Area Number: 26242044
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Showa University
• Principal Investigator: Yamakoshi Ken-ichi 昭和大学, 医学部, 客員教授 (40014310)
• Co-Investigator(Kenkyū-buntansha): 加藤 祐次 北海道大学, 情報科学研究科, 助教 (50261582) ; 山越 健弘 福岡工業大学, 情報工学部, 准教授 (70444205) ; 李 知炯 福岡工業大学, 情報工学部, 助教 (10735583) ; 清水 孝一 北海道大学, 情報科学研究科, 教授 (30125322)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 糖尿病 / 非侵襲光学的血糖計測 / パルス・グルコメトリ / グルコース吸収波長帯域 / 積分球式光電容積信号検出法 / 側方入射型光電容積信号検出法 / 光散乱現象 / 偏光変調型光電容積信号検出法

Outline of Final Research Achievements

According to a statement issued by International Diabetes Federation, diabetes population in 2015 runs up to 415 million people and Japan has diabetes powers ranked 9th in the world. In a diabetic patient blood glucose (BGL) measurement, most desirably non-invasive method without blood sampling, is needed to control BGL level. Unfortunately such practical non-invasive method has not yet been developed up to now.
We have previously developed a novel non-invasive BGL measurement using a finger called “pulse glucometry” and evaluated its validity on an experimental basis. To realize technical practicability of this method, it is essential to develop a new finger-photoplethysmography (PPG) in a wavelength region with BGL absorption having quite high accuracy and sensitivity as well as convenient use. The present study was carried out focusing especially on this PPG development, aiming a basic establishment towards the world’s first non-invasive BGL measurement device for practical use.

Free Research Field

人間医工学：生体計測と制御、非侵襲生体計測、ヘルスケアモニタリング、バイオメカニクス