2017 Fiscal Year Final Research Report
The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseases
| Project/Area Number |
26242048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI FUMINORI 大阪大学, 大学院・薬学研究科, 准教授 (70370939)
TACHIBANA MASASHI 大阪大学, 大学院・薬学研究科, 助教 (80513449)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | ウイルス / 遺伝子 / 癌 / 免疫学 / バイオテクノロジー |
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| Outline of Final Research Achievements |
In this study, we developed several types of novel recombinant adenoviruses (Ad) for the treatment, prevention, and diagnosis of diseases. We developed Cas9-expressing adenovirus vector for genome editing. We analyzed the mechanism how intramuscular vaccination of an adenovirus vector promotes the induction of antigen-specific gut-mucosal CTLs. We also developed a novel detection system of circulating tumor cells using a green fluorescence protein-expressing conditionally replicating adenovirus.
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| Free Research Field |
分子生物学
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