2017 Fiscal Year Final Research Report
Creation of novel molecular-targeted anticancer drugs focused on specific phenotypic changes of cells in tumor
| Project/Area Number |
26242074
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
荒井 雅吉 大阪大学, 薬学研究科, 特任教授(常勤) (80311231)
古徳 直之 大阪大学, 薬学研究科, 助教 (20362618)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 抗がん剤 / がん微小環境 / 標的分子 / 海洋生物 / 分子標的治療薬 |
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| Outline of Final Research Achievements |
In this study, we focused on metabolic or phenotypic changes of cells in tumor microenvironments and searched for marine natural products capable of regulating them. Then, 10 bioactive natural products including 7 novel compounds were discovered. In addition, total synthesis of isolated bioactive natural products, study of structure- activity relationship by synthesized analog compounds, and evaluation of in vivo efficacy were carried out. Furthermore, for the purpose of exploring new drug targets, we analyzed the action-mechanisms and target molecule of bioactive natural products. As a result, the action-mechanism or target molecule of 5 compounds were clarified.
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| Free Research Field |
天然物化学
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