2018 Fiscal Year Final Research Report

Development of Supramolecular Sensing and Separation Systems Based on Nano-size Inclusion Cavities

Research Project

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Project/Area Number	26248038
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Analytical chemistry
Research Institution	Sophia University
Principal Investigator	Hayashita Takashi 上智大学, 理工学部, 教授 (70183564)
Co-Investigator(Kenkyū-buntansha)	江馬一弘上智大学, 理工学部, 教授 (40194021) 南部伸孝上智大学, 理工学部, 教授 (00249955) 遠藤明上智大学, 理工学部, 准教授 (00119124) 橋本剛上智大学, 理工学部, 准教授 (20333049)
Project Period (FY)	2014-06-27 – 2019-03-31
Keywords	シクロデキストリン / 疎水ナノ空間 / 糖認識 / アニオン認識 / 細菌認識 / 超分子複合体 / 光物性解析 / 分子軌道計算
Outline of Final Research Achievements	In this study, we have developed various supramolecular sensing and separation systems for constructing a more efficient ion and molecule recognition. These systems are based on a combination of various molecular probes with cyclodextrins possessing nano-size cavities by using inclusion complex formation and weak intermolecular interactions. In the combination of ditopic azoprobes with cyclodextrins, the novel supramolecular chirality based on twisted structure of two probes inside cyclodextrin cavity was found to be induced only in the presence of specific metal ions and anions. Furthermore by employing these molecular recognition sites on various nanoparticles such as silica nanoparticle and dendrimers, novel bacteria detection systems have been successfully developed.
Free Research Field	分析化学、超分子化学
Academic Significance and Societal Importance of the Research Achievements	全く新しい分析試薬を開発するための新しい方法論として、ナノ空間包接場を用いる超分子計測・分離システムを開発できた点に学術的意義がある。また本研究で開発した超微細CDナノゲルが医薬品や食品分野での活用が期待できる点、およびフェニルボロン酸型デンドリマーなどのナノ構造体が、細菌種を識別・分離できる新しい材料となることを見出したことは、今後、細菌汚染を防ぐ安全環境保全に繋がる技術として、社会的な意義があると言える。