脳内双方向通信マイクロフォトニックデバイスの研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 26249051
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: 太田 淳 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)
• Co-Investigator(Kenkyū-buntansha): 田村 英紀 星薬科大学, 付置研究所, 講師 (80437516)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 生体内埋植デバイス / CMOSイメージセンサ / 光遺伝学

Outline of Annual Research Achievements

１．埋植デバイス高性能化：デバイスの低侵襲化を引き続き行い，侵襲性を免疫染色等で評価した．また既に奈良先端大で導入している光応答膜タンパクであるChR2を導入した遺伝子改変マウスを用いて埋植デバイスによる神経細胞への光刺激を行う実験を行った．連携研究者徳田が以前設計したチップを元に新たに光電気刺激可能な小型チップを設計した．光電気刺激機能はイメージングチップ上への集積化と別チップとするものとを試作する． これらの試作には本年度申請のマイクロチップ電気光学特性評価設備を用いる．
２．ネットワーク回路との双方向通信：前年度に引き続き海馬と扁桃体など複数部位への埋植を行い），複数部位間の神経活動における関係性を評価した．GABA以外にドーパミンについても遺伝子改変マウスを用いて側座核等への埋植によりその活性を計測した．
３．生体外通信方式：昨年度検討した方式を元に，光による生体外通信方式についての検討を進め，チップの試作を行い画像通信に成功した．

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

当初予定の3つの項目，１．埋植デバイス高性能化，２． ネットワーク回路との双方向通信，３．生体外通信方式の各々について，当初の計画に沿った内容の成果を得ることができたため．なお生体外通信方式は，RFではなく光で行うことを現在進めており，これは当初計画になかったことであるが，現状同様な効果を発揮する方式として検討を進めている．

Strategy for Future Research Activity

3つの研究項目のうち，１． 埋植デバイス高性能化，２． ネットワーク回路との双方向通信に関しては，当初の計画通りに進めていく．３．生体外通信方式についてはこれまで光通信方式について検討を進め，チップ試作等を行い，一定の成果を収めているが，今後はRF方式についても実験を行っていく．

Research Products

• [Journal Article] Implantable micro-optical semiconductor devices for optical theranostics in deep tissue (2016)
  • Author(s): Hiroaki Takehara, Yuji Katsuragi, Yasumi Ohta, Mayumi Motoyama, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
  • Journal Title: Applied Physics Express (APEX) Volume: 9 Pages: 047001-1~4
  • DOI: 10.7567/APEX.9.047001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging (2016)
  • Author(s): Takuma Kobayashi, Makito Haruta, Kiyotaka Sasagawa, Miho Matsumata, Kawori Eizumi, Chikara Kitsumoto, Mayumi Motoyama, Yasuyo Maezawa, Yasumi Ohta, Toshihiko Noda, Takashi Tokuda, Yasuyuki Ishikawa, Jun Ohta
  • Journal Title: Scientific Reportｓ Volume: 6 Pages: 1~13
  • DOI: 10.1038/srep21247
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Wireless Image-Data Transmission from an Implanted Image Sensor through a Living Mouse Brain with Intra-Body Communication (2016)
  • Author(s): Hajime Hayami, Hiroaki Takehara, Kengo Nagata, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa*, Takashi Tokuda and Jun Ohta
  • Journal Title: Jpn. J. Appl. Phys. Volume: 55 Pages: 04EM03-1~5
  • DOI: 10.7567/JJAP.55.04EM03
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Implantable self-reset CMOS image sensor and its application to hemodynamic response detection in living mouse brain (2016)
  • Author(s): Takahiro Yamaguchi, Hiroaki Takehara, Yoshinori Sunaga, Makito Haruta, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Journal Title: Jpn. J. Appl. Phys. Volume: 55 Pages: 04EM02-1~6
  • DOI: 10.7567/JJAP.5504EM02
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] "Implantable Imaging Device for Brain Functional Imaging System using Flavoprotein Fluorescence" (2016)
  • Author(s): Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguchi,Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura, and Jun Ohta
  • Journal Title: Jpn. J. Appl. Phys. Volume: 55 Pages: 03DF02-1~5
  • DOI: 10.7567/JJAP.55.03DF02
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CMOS-Based Optoelectronic On-Chip Neural Interface Device (2016)
  • Author(s): Takashi Tokuda,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Jun Ohta
  • Journal Title: IEICE TRANSACTIONS on Electronics Volume: E99-C Pages: 165~172
  • DOI: 10.1587/tranele.E99.C165
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fluorescence imaging under background light with a self-reset CMOS image sensor (2016)
  • Author(s): Takahiro Yamaguchi,Yoshinori Sunaga,Makito Haruta,Mayumi Motoyama,Yasumi Ohta,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Takashi Tokuda,Jun Ohta
  • Journal Title: The Journal of Engineering Volume: - Pages: 1~3
  • DOI: 10.1049/joe.2015.0046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An Implantable CMOS Image Sensor with Self-Reset Pixels for Functional Brain Imaging (2016)
  • Author(s): Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yoshinori Sunaga, Hironari Takehara, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, and Jun Ohta
  • Journal Title: IEEE Transactions on Electron Devices Volume: 63 Pages: 215~222
  • DOI: 10.1109/TED.2015.2454435
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intravital fluorescence imaging of mouse brain using implantable semiconductor devices and epi-illumination of biological tissue (2015)
  • Author(s): Hiroaki Takehara, Yasumi Ohta, Mayumi Motoyama, Makito Haruta, Mizuki Nagasaki, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Journal Title: Biomedical Optics Express Volume: 6 Pages: 1553~1564
  • DOI: 10.1364/BOE.6.001553
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 埋植型デバイスの導入に向けたハイドロゲルの光学特性評価 (2016)
  • Author(s): 桂木 優治,須永 圭紀,竹原 宏明,野田 俊彦,笹川 清隆,徳田 崇,太田 淳
  • Organizer: 応用物理学会春季学術講演会
  • Place of Presentation: 東工大 大岡山キャンパス 東京都目黒区
  • Year and Date: 2016-03-20
• [Presentation] CMOSイメージセンサを用いた培養細胞のオンチップ蛍光計測システム (2016)
  • Author(s): 大澤 和嵩，竹原 宏明，野田 俊彦，笹川 清隆，徳田 崇，太田 淳
  • Organizer: 応用物理学会春季学術講演会
  • Place of Presentation: 東工大 大岡山キャンパス 東京都目黒区
  • Year and Date: 2016-03-20
• [Presentation] A fluorescence imaging device with a portable system for detection of nitric oxide (2016)
  • Author(s): Anek Wuthayavanich, Makito Haruta,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Takashi Tokuda,Jun Ohta
  • Organizer: 応用物理学会春季学術講演会
  • Place of Presentation: 東工大 大岡山キャンパス 東京都目黒区
  • Year and Date: 2016-03-20
• [Presentation] 生体内埋植 マイクロエレクトロニクスデバイス (2016)
  • Author(s): 太田 淳
  • Organizer: 電気学会全国大会シンポジウム
  • Place of Presentation: 東北大学川内北キャンパス，宮城県仙台市
  • Year and Date: 2016-03-17
  • Invited
• [Presentation] 光電子デバイス技術による生体計測と刺激 (2016)
  • Author(s): 太田 淳
  • Organizer: 第44回脳神経科学コアセンサーセミナー
  • Place of Presentation: 東北大学片平キャンパス，宮城県仙台市
  • Year and Date: 2016-03-17
  • Invited
• [Presentation] ここまで進んだ人工の目 (2016)
  • Author(s): 太田 淳
  • Organizer: あづみ野ロータリークラブ創立30周年記念講演会
  • Place of Presentation: 豊科交流学習センター，長野県安曇野市
  • Year and Date: 2016-02-27
  • Invited
• [Presentation] 体内埋込デバイスによる生体刺激と機能イメージング (2016)
  • Author(s): 太田 淳
  • Organizer: "第８７回表面科学研究会 平成２７年度中部表面科学シンポジウム"
  • Place of Presentation: 名城大学名駅サテライト，愛知県名古屋市
  • Year and Date: 2016-01-23
  • Invited
• [Presentation] マイクロフォトニックデバイスのバイオ医療応用 (2016)
  • Author(s): 太田 淳
  • Organizer: 京都工芸繊維大学 ヘルスサイエンス教育研究拠点 講演会
  • Place of Presentation: 京都工芸繊維大学６０周年記念ホール，京都府京都市
  • Year and Date: 2016-01-13
  • Invited
• [Presentation] イメージセンサのバイオ医療応用 (2015)
  • Author(s): 太田 淳
  • Organizer: 学振第179委員会第41回研究会
  • Place of Presentation: 弘済会館，東京都千代田区
  • Year and Date: 2015-12-11
  • Invited
• [Presentation] Development of a small imaging device and USB operating system for detecting nitric oxide (2015)
  • Author(s): "Anek Wuthayavanich, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta"
  • Organizer: Bio4Apps 2015
  • Place of Presentation: Ito campus,Kyushu University, Fukuoka, Japan
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] CMOS-Based on-Chip Neural Interface Devices for Optogenetics (2015)
  • Author(s): Takashi Tokuda, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, and Jun Ohta
  • Organizer: Biomedical Circuits and Systems Conference 2015 (BioCAS2015)
  • Place of Presentation: Historic Academy of Medicine in Atlanta, USA
  • Year and Date: 2015-10-23
  • Int'l Joint Research
• [Presentation] Image sensors and their applications to implantable biomedical devices (2015)
  • Author(s): Jun Ohta
  • Organizer: Biomedical Circuits and Systems Conference 2015 (BioCAS2015)
  • Place of Presentation: Historic Academy of Medicine in Atlanta, USA
  • Year and Date: 2015-10-22
  • Int'l Joint Research / Invited
• [Presentation] Improvement of green fluorescence imaging system based on implantable CMOS imaging device for freely moving mice (2015)
  • Author(s): Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguch1, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura and Jun Ohta
  • Organizer: Neuroscience 2015 SfN 45th annual meeting
  • Place of Presentation: McCormick Place Convention Center,Chicago,USA
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] An implantable hemodynamic imaging device for revealing relation between a blood flow and brain activity in animal behavior (2015)
  • Author(s): Makito Haruta,Yoshinori Sunaga,Takahiro Yamaguchi, Hironari Takehara.Yasumi Ohta,Mayumi Motoyama,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Takashi Tokuda,Jun Ohta.
  • Organizer: Neuroscience 2015 SfN 45th annual meeting
  • Place of Presentation: McCormick Place Convention Center,Chicago,USA
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Image processing technique for an implantable image sensor with self-resetting function (2015)
  • Author(s): Kiyotaka Sasagawa, Takahiro Yamaguchi, Makito Haruta, Yoshinori Sunaga, Hironari Takehara, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Takashi Tokuda, Jun Ohta
  • Organizer: Neuroscience 2015 SfN 45th annual meeting
  • Place of Presentation: McCormick Place Convention Center,Chicago,USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Visualizing neuronal activities of the deep brain in a freely-moving mouse by using implantable micro imaging devices (2015)
  • Author(s): Yasumi Ohta, Mayumi Motoyama, Makito Haruta Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: Neuroscience 2015 SfN 45th annual meeting
  • Place of Presentation: McCormick Place Convention Center,Chicago,USA
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Implantable CMOS imaging devices (2015)
  • Author(s): Jun Ohta
  • Organizer: 4th International Symposium on Bioelectronics and Bioinformatics
  • Place of Presentation: Tsinghua University Rohm Hall, China
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] "半導体集積化技術による バイオ医療応用デバイス ～ミニマルのバイオ分野応用への期待～" (2015)
  • Author(s): 太田 淳
  • Organizer: ファブシステム研究会『H27 臨時総会
  • Place of Presentation: 産総研・つくば中央第1事業所，茨城県つくば市
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] An Implantable Needlelike Shaped Device and Its Performance in Lensless Fluorescence Imaging of Biological Tissues (2015)
  • Author(s): Hiroaki Takehara, Yasumi Ohta, Mayumi Motoyama, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
  • Organizer: 2015 International Conference on Sold State Devices and Materials
  • Place of Presentation: Sapporo Convention Center, Japan
  • Year and Date: 2015-09-30
• [Presentation] "Wireless Data Transmission in a Brain Tissue with Intra-Body Communication by a Micro-Sized Image Sensor" (2015)
  • Author(s): Hajime Hayami, Kengo Nagata, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 2015 International Conference on Sold State Devices and Materials
  • Place of Presentation: Sapporo Convention Center, Japan
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] "Improvement of Power Consumption and SNR of Self-reset Pixels for an Implantable CMOS Image Sensor" (2015)
  • Author(s): Takahiro Yamaguchi,Yoshinori Sunaga, Makito Haruta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 2015 International Conference on Sold State Devices and Materials
  • Place of Presentation: Sapporo Convention Center, Japan
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] [有機分子・バイオエレクトロニクス分科会論文賞受賞記念講演] ラボ・オン・ブレイン：In vivo神経科学研究のための埋め込み型マイクロオプト流体デバイス (2015)
  • Author(s): 竹原宏明
  • Organizer: 応用物理学会秋季学術講演会
  • Place of Presentation: 名古屋国際会議場 愛知県名古屋市
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] 埋植用自己リセット型 CMOS イメージセンサによる内因性シグナルの検出 (2015)
  • Author(s): 山口 貴大, 須永 圭紀, 春田 牧人, 元山 真由美, 太田 安美, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 応用物理学会秋季学術講演会
  • Place of Presentation: 名古屋国際会議場 愛知県名古屋市
  • Year and Date: 2015-09-15
• [Presentation] An Implantable Hemodynamic Imaging Device for Observing the Process of Recovery from Cerebrovascular Disease (2015)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Takahiro Yamaguchi, Hironari Takehara, Yasumi Ohta, Mayumi Motoyama, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
  • Organizer: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: MiCo, Milano Conference Center, Italy
  • Year and Date: 2015-08-28
  • Int'l Joint Research
• [Presentation] An implantable hemodynamic imaging device with a two-color light source for observing two brain phenomena (2015)
  • Author(s): Makito Haruta, Yoshinori Sunaga, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, and Jun Ohta
  • Organizer: 2015 INTERNATIONAL SYMPOSIUM FOR ADVANCED MATERIALS RESEARCH
  • Place of Presentation: SUN MOON LAKE TEACHERS' HOSTEL, Taiwan
  • Year and Date: 2015-08-19
  • Invited
• [Presentation] 動物の脳機能制御を可能にする無線多点光刺激デバイス (2015)
  • Author(s): Makito Haruta, , Naoya Kamiyama, Takahiro Yamaguchi, Mayumi Motoyama, Mamiko Kawahara, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際展示場 兵庫県神戸市
  • Year and Date: 2015-07-29
• [Presentation] 自由行動下マウス脳内神経活動の計測を目的とした埋植用微小イメージングデバイス (2015)
  • Author(s): 太田安美、元山真由美、春田牧人、竹原宏明、野田俊彦、笹川清隆、徳田崇、太田淳
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際展示場 兵庫県神戸市
  • Year and Date: 2015-07-29
• [Presentation] 光電子デバイスのバイオメディカル分野への応用 (2015)
  • Author(s): 太田 淳
  • Organizer: 第2回フォトニックデバイス・応用技術研究会
  • Place of Presentation: 機械振興会館，東京都港区
  • Year and Date: 2015-07-22
  • Invited
• [Presentation] 埋め込み可能な小型脳血流イメージングデバイスの開発 (2015)
  • Author(s): 春田 牧人、須永 圭紀、山口 貴大、竹原 浩成 太田 安美、元山 真由美、竹原 宏明、野田 俊彦、笹川 清隆、徳田 崇 、太田 淳
  • Organizer: 電気学会E部門総合研究会
  • Place of Presentation: 九州大学医学部百年講堂 福岡県福岡市
  • Year and Date: 2015-07-03
• [Presentation] Implantable Imaging Device for Brain Functional Imaging System using Flavoprotein Fluorescence (2015)
  • Author(s): Yoshinori Sunaga, Hiroshi Yamaura, Makito Haruta, Takahiro Yamaguchi, Mayumi Motoyama, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yumiko Yoshimura and Jun Ohta
  • Organizer: M&BE8
  • Place of Presentation: Tower Hall Funabori, Tokyo, Japan
  • Year and Date: 2015-06-22
  • Int'l Joint Research
• [Presentation] Post Scaling: What will be next? (2015)
  • Author(s): Jun Ohta
  • Organizer: VLSI Symposium
  • Place of Presentation: Rihga Royal Hotel, Kyoko, Japan
  • Year and Date: 2015-06-16
  • Int'l Joint Research / Invited
• [Presentation] [ISSCC Tutorial解説] 「Interfacing Silicon with the human Body: a primer on applications, interface circuits and Technologies for the Medical Market」 (2015)
  • Author(s): 太田 淳
  • Organizer: LSIとシステムのワークショップ2015
  • Place of Presentation: 北九州国際会議場、福岡県北九州市
  • Year and Date: 2015-05-13
  • Invited
• [Presentation] 多点埋植型PWM出力イメージセンサを用いた神経ネットワーク計測システム (2015)
  • Author(s): 速水 一, 永田 健悟, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: LSIとシステムのワークショップ2015
  • Place of Presentation: 北九州国際会議場、福岡県北九州市
  • Year and Date: 2015-05-11
• [Presentation] 埋植用自己リセット型イメージセンサの低発熱化によるSNR向上 (2015)
  • Author(s): 山口 貴大, 須永 圭紀, 春田 牧人, 竹原 宏明, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: LSIとシステムのワークショップ2015
  • Place of Presentation: 北九州国際会議場、福岡県北九州市
  • Year and Date: 2015-05-11
• [Presentation] 半導体イメージセンサを用いた脳深部光イメージング技術 (2015)
  • Author(s): 竹原 宏明
  • Organizer: 国際光年記念シンポジウム
  • Place of Presentation: 東京大学本郷キャンパス 東京都文京区
  • Year and Date: 2015-04-21
• [Presentation] Optoelectronic Devices for Biomedical Applications (2015)
  • Author(s): Jun Ohta
  • Organizer: ICEP-IAAC2015
  • Place of Presentation: Kyoto Terrsa, Kyoto, Japan
  • Year and Date: 2015-04-15
  • Int'l Joint Research / Invited
• [Presentation] Implantable semiconductor imaging devices for in vivo optical imaging of brain (2015)
  • Author(s): Hiroaki Takehara, Makito Haruta, Yasumi Ohta, Mayumi Motoyama, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
  • Organizer: The Optics in the Life Sciences Congress, Optics and the Brain
  • Place of Presentation: Pinnacle Vancouver Harbourfront Hotel、Canada
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Remarks] 光機能素子科学研究室
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