Multiple functional electron paramagnetic resonance imaging for quantitative cancer studies

2017 Fiscal Year Final Research Report

• Project/Area Number: 26249057
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Hokkaido University
• Principal Investigator: Hirata Hiroshi 北海道大学, 情報科学研究科, 教授 (60250958)
• Co-Investigator(Kenkyū-buntansha): 安井 博宣 北海道大学, アイソトープ総合センター, 准教授 (10570228)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 電子スピン共鳴 / 酸素分圧 / pH / 腫瘍 / イメージング

Outline of Final Research Achievements

We developed the methods of continues-wave electron spin resonance (ESR) imaging for the visualization of oxygen partial pressure and pH of tumor tissues. Using accelerated four-dimensional spectral-spatial imaging, mapping of oxygen partial pressure and pH performed. ESR imaging recorded relaxation time T2* of oxygen-sensitive spin probes and ESR spectral lines of a pH-sensitive spin probe for oxygen mapping and pH mapping. Estimations of oxygen partial pressure and pH used those spectral parameters. Finally, we tested the developed methods with solution phantoms and tumor-bearing mice.

Free Research Field

計測工学