2018 Fiscal Year Final Research Report
Membrane-on-Membrane ~Creation of Hierarchical Self-Organizing Materials~
| Project/Area Number |
26249116
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菅 恵嗣 大阪大学, 基礎工学研究科, 助教 (00709800)
島内 寿徳 岡山大学, 環境生命科学研究科, 准教授 (10335383)
林 啓太 奈良工業高等専門学校, 物質化学工学科, 講師 (10710783)
岡本 行広 大阪大学, 基礎工学研究科, 准教授 (50503918)
中村 秀美 奈良工業高等専門学校, 物質化学工学科, 教授 (70198232)
塩盛 弘一郎 宮崎大学, 工学部, 教授 (80235506)
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| Research Collaborator |
Ishigami Takaaki
Iwasaki Fumihiko
Hirose Masanori
Taguchi Shogo
Watanabe Nozomi
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Keywords | Membranome / Membrane on Membrane / リポソーム / キラル認識 / 不斉合成 / 分子認識 / ナノドメイン / 表層水和水 |
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| Outline of Final Research Achievements |
In this project, a novel membranous devise (material) was developed. Membrane-on-Membrane (MoM) was hierarchically composed by self-assembled membranes. Liposome was selected as core unit of MoM, because it showed unique functions such as recognition of L-amino acid, promoting organic reaction in water, and molecular orientation of chlorophyll. In addition, the methodologies, multiple-fluorescent probe analyses, membrane surface-enhanced Raman spectroscopy, dielectric dispersion (relaxation) spectroscopy, were developed to characterize the physicochemical properties of membranes (in micro- and mesoscale). As an example of our achievements, the “ordered” membrane property plays a crucial role to improve selectivity in chiral recognition of amino acid. When the liposome possessing ordered membrane property was applied to MoM device (for example, liposome-immobilized polyacrylamide hydrogel system), the chiral recognition ability could be maintained.
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| Free Research Field |
Bio-Inspired化学工学
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| Academic Significance and Societal Importance of the Research Achievements |
Liposome膜は，酵素に類似した分子認識・変換機能(LIPOzyme機能)を誘導する事が示されている．一連の成果は世界的に見て類のない研究であり，当研究Gr.が発信した独創的な機能性材料である．近年では生体模倣(Biomimetic)材料が多数報告されているが，結局のところ，生体系由来の機能を付与した材料に留まっている．本研究で得た一連の知見では，自己組織化膜のしなやかな構造を最大限に活用し，酵素と同様に構造ゆらぎにより認識/変換を制御しているため(Bio-Inspired)，従来にはない独創的研究といえる．さらにMoMは状態に応じて進化しうる材料であり，極めて進歩的な技術開発といえる．
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