2016 Fiscal Year Final Research Report
Molecular mechanism of epigenetic regulation of mammalian sex differentiation
| Project/Area Number |
26250037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TACHIBANA Makoto 徳島大学, 先端酵素学研究所(次世代), 教授 (80303915)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEMOTO Keiko 京都大学, ウイルス研究所, 助教 (90243104)
MIYACHI Hitoshi 京都大学, ウイルス研究所, 技術専門職員 (90599200)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ヒストン / メチル化 / 性決定 |
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| Outline of Final Research Achievements |
Epigenetic regulation by covalent modification of histone tails play crucial roles on a wide range of biological processes in mammal. Previously we found that histone demethylation is required for mammalian sex differentiation. Based on this finding, we further studied the roles of epigenetic regulation for sex differentiation. We found that the expression level of mammalian sex-determining gene is finely tuned by the antagonistic activities between histone demethylation and methylation.
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| Free Research Field |
分子生物学
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