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2016 Fiscal Year Final Research Report

Molecular mechanism of epigenetic regulation of mammalian sex differentiation

Research Project

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Project/Area Number 26250037
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Genome biology
Research InstitutionThe University of Tokushima

Principal Investigator

TACHIBANA Makoto  徳島大学, 先端酵素学研究所(次世代), 教授 (80303915)

Co-Investigator(Renkei-kenkyūsha) TAKEMOTO Keiko  京都大学, ウイルス研究所, 助教 (90243104)
MIYACHI Hitoshi  京都大学, ウイルス研究所, 技術専門職員 (90599200)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsヒストン / メチル化 / 性決定
Outline of Final Research Achievements

Epigenetic regulation by covalent modification of histone tails play crucial roles on a wide range of biological processes in mammal. Previously we found that histone demethylation is required for mammalian sex differentiation. Based on this finding, we further studied the roles of epigenetic regulation for sex differentiation. We found that the expression level of mammalian sex-determining gene is finely tuned by the antagonistic activities between histone demethylation and methylation.

Free Research Field

分子生物学

URL: 

Published: 2018-03-22  

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