2018 Fiscal Year Final Research Report
Study on molecular machinery of suppression of neurodegeneration by autophagy and drug discovery research
| Project/Area Number |
26251020
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Keywords | オートファジー / 神経変性疾患 |
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| Outline of Final Research Achievements |
The intracellular degradation system, autophagy is known to degrade aggregate-prone proteins causing neurodegeneration including Parkinson disease. We found that suppression of Rubicon, a negative regulator of autophagy enhances these proteins. In addition, we identified several Low molecular weight compounds, which are candidates for activating autophagy thereby promote degradation of the proteins.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病やパーキンソン病等の神経変性疾患は、超高齢社会を迎える我が国の重要課題です。それを抑える細胞の仕組みの一端を明らかにできたことと、そしてその結果治療の標的となりうるタンパク質が判ったことは学術的にも社会的にも大きな意義があります。さらにこの研究で発見したオートファジーを促進する化合物は、将来これらの病気の治療薬の開発に結びつくことが期待されます。
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