Study on enteroendocrine, nervous and reproductive systems related to diet for preventing metabolic diseases.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26252016
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: Hara Hiroshi 北海道大学, 農学研究院, 教授 (70198894)
• Co-Investigator(Kenkyū-buntansha): 比良 徹 北海道大学, (連合)農学研究科(研究院), 講師 (10396301)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 消化管内分泌系 / 食事組成 / GLP-1

Outline of Final Research Achievements

In this project, we investigated gut hormone secretory responses to ‘meal’in the conscious animal model equipped with portal cannula. We have found that gut hormone responses (such as GLP-1, GIP,PYY, Ghrelin) are modified by changing the source of dietary proteins. Furthermore, the effect of dietary protein was modified by the source of carbohydrates in the meal.
Feeding the diet supplemented with resistant maltodextrin which has GLP-1-releasing activity prevented excess energy intake induced by high fat high sucrose diet.
Our results suggest that postprandial gut hormone responses can be desirably manipulated by changing the composition of a meal.

Free Research Field

食品栄養学