Empirical research for bovine leukemia control strategy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26252051
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Hokkaido University
• Principal Investigator: KONNAI SATORU 北海道大学, 獣医学研究院, 准教授 (40396304)
• Co-Investigator(Kenkyū-buntansha): 村田 史郎 北海道大学, 獣医学研究院, 助教 (10579163) ; 大橋 和彦 北海道大学, 獣医学研究院, 教授 (90250498)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 牛白血病 / 牛白血病ウイルス / 伝播リスク / ウイルス定量 / 清浄化モデル / プロウイルス / リンパ球数 / 免疫抑制

Outline of Final Research Achievements

Bovine leukemia virus (BLV) is highly endemic in many countries including Japan. In this study, we evaluated the risk for BLV transmission among the infected animals to establish the guideline for effective eradication of EBL. We found that BLV-infected cattle with persistent lymphocytosis (PL) or high proviral load or EBL are considered major sources of both horizontal and vertical BLV transmission. Furthermore, maternal proviral load is closely correlated with the frequency of vertical transmission to calves. However, no direct evidence of intrauterine BLV infection has been confirmed in infected cattle. We confirmed intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery, and BLV was detected in the newborns. In the study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.

Free Research Field

感染免疫、腫瘍免疫、臨床免疫