Synthetic Studies on Complex Alkaloids base on Development of Creative Construction of Complex Skeleton and Oxidative Transformations

2017 Fiscal Year Final Research Report

• Project/Area Number: 26253001
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Tokuyama Hidetoshi 東北大学, 薬学研究科, 教授 (00282608)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: アルカロイド / 全合成 / 骨格構築 / 酸化反応

Outline of Final Research Achievements

Synthetic studies on pharmacologically important and structurally complex natural products were conducted based on development of novel oxidative transformations and constructions of the unique skeletons. As results, we established synthetic route of the number of synthetically challenging alkaloids such as MPC1001 B, asteroxepin, historionicotoxin, lepadiformine A, indolactam V, CC-1065, isoschizogamine, haplophytine, leuconoxine and its congeners. We also developed the synthetic method for tetracyclic core skeleton of aconitine alkaloid.

Free Research Field

有機合成化学