Comprehensive study for practical use of a total implantable total artificial heart with small size and high performance.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26253071
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Abe Yusuke 東京大学, 大学院医学系研究科(医学部), 准教授 (90193010)
• Co-Investigator(Renkei-kenkyūsha): ONO Minoru 東京大学, 医学部付属病院, 教授 (40270871) ; ISIHARA Kazuhiko 東京大学, 大学院工学系研究科, 教授 (90193341) ; TAKAI Madoka 東京大学, 大学院工学系研究科, 教授 (40287975) ; ISOYAMA Takashi 東京大学, 大学院医学系研究科, 講師 (20302789) ; SAITO Itsuro 東京大学, 大学院医学系研究科, 特任研究員 (80334225) ; HARA Shintaro 東京大学, 大学院医学系研究科, 特任研究員 (00791112)
• Research Collaborator: INOUE Yusuke 東北大学, 加齢医学研究所, 助教 (80611079) ; SATO Masami ; LI Xin-Yang ; YURIMOTO Terumi ; MURAKAMI Haruka ; ARIYOSHI Kouki ; KAWASE Yukino ; TASHIRO Ayaka ; KAWASE Yukino ; MIZUTA Sora ; HAWAI Yoshinori ; HIGO Keiya ; ONO Toshiya 東京大学, 大学院医学系研究科, 技術専門員
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 人工心臓 / 螺旋流ポンプ / 血流量制御 / 圧流量推定 / エネルギー伝送 / 血圧センサー / ハイブリッドパーツ

Outline of Final Research Achievements

The total artificial heart (TAH) is expected to be an ultimate device for heart replacement. To realize practical use of a total implantable total artificial heart, the second model of the helical flow TAH that was designed to be small and to have long-term durability was developed using helical flow pumps. A new physiological control method named the delta P control was developed based on the 1/R control method. To develop implantable controller for the TAH, an implantable pressure sensor was developed. A novel pressure and flow estimation method using reference tables was developed. The transcutaneous energy transmission system using flexible coils made with polyimide film was developed to obtain good anatomical fitting for implantation of the coil. New canulae and atrial cuffs made of hybrid parts that were constructed with fusion of artificial material and biological material were developed.

Free Research Field

医用工学、一般外科学