2016 Fiscal Year Final Research Report
Host nuclear network responsible for the pathology of virus infection
| Project/Area Number |
26253083
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Akita University |
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Principal Investigator |
IMAI Yumiko 秋田大学, 医学(系)研究科(研究院), 教授 (50231163)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ウィルス / 集中治療 / エピゲノム |
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| Outline of Final Research Achievements |
We investigated the mechanisms involved in the pathology of severe influenza virus infection focusing virus host nuclear interactions. We found a influenza virus RNA specific RNA nuclear export pathway mediated by NXF1. Also, we found that host epigenetic modifications in particular histone methylation play critical role in controlling the pathology of influenza virus infection, which could be a potential therapeutic target for severe influenza.
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| Free Research Field |
集中治療・ウイルス・エピジェネティクス
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