• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Annual Research Report

Formation factors of physiological activity and ecological impact level among east Asia and England

Research Project

Project/Area Number 26257302
Research InstitutionKyoto University

Principal Investigator

田中 宏明  京都大学, 工学研究科, 教授 (70344017)

Co-Investigator(Kenkyū-buntansha) 中田 典秀  京都大学, 工学研究科, 助教 (00391615)
宮川 信一  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), その他部局等, 助教 (30404354)
井原 賢  京都大学, 工学研究科, 特定助教 (70450202)
井口 泰泉  横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 特任教授 (90128588)
山下 尚之  京都大学, 工学研究科, 講師 (90391614)
李 善太  京都大学, 工学研究科, 特定研究員 (60771962)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords生理活性 / 医薬品類 / 化学分析 / 河川 / 下水 / 下水処理 / 膜分離活性汚泥法 / モデル
Outline of Annual Research Achievements

本研究は、以下の(1)~(5)からなり、英国、中国、韓国の下水処理場と河川での現地調査と現地での前処理、日本国内でのエストロゲンと医薬品類の分析をLC/MS/MSで、生理活性作用をTGFα切断アッセイで測定するとともに、医薬品類の下水、下水処理水、河川水での濃度推定を行うためのモデルを検討した。
(1)中国での下水処理場の現地採水(2)TGFα切断アッセイによる環境水の生理活性の総括的把握(3)医薬品類の化学分析とアッセイ換算等量(4)MBRなどの医薬品分解過程の把握と推定(5)河川での分解過程のモデル化
また、韓国での第3回アジア再利用会議国際会議、英国との共同研究を議論するため、日本で開催された第19回日英内分泌かく乱物質共同研究ワークショップ、欧州での国際会議や国内の学会などで成果を発表し、議論するとともに、国際誌などに成果を発表した。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

  • Research Products

    (25 results)

All 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results) Presentation (14 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results)

  • [Int'l Joint Research] 水文生態研究所/Brunel大学/Exter大学(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      水文生態研究所/Brunel大学/Exter大学
    • # of Other Institutions
      1
  • [Int'l Joint Research] 清華大学/深セン水務集団(中国)

    • Country Name
      CHINA
    • Counterpart Institution
      清華大学/深セン水務集団
  • [Int'l Joint Research] ソウル市立大学校/韓国建設技術院(韓国)

    • Country Name
      KOREA (REP. OF KOREA)
    • Counterpart Institution
      ソウル市立大学校/韓国建設技術院
  • [Journal Article] Source estimation of pharmaceuticals based on catchment population and in-stream attenuation in Yodo River watershed, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Yamashita, N., Tanaka, H.
    • Journal Title

      Science of the Total Environment

      Volume: 615 Pages: 964ー971

    • DOI

      https://doi.org/10.1016/j.scitotenv.2017.10.013

    • Peer Reviewed
  • [Journal Article] The different fate of antibiotics in the Thames River, UK, and the Katsura River, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Johnson, AC., Jürgens, MD., Yamashita, N., Tanaka, H.
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 25 Pages: 1903-1913

    • DOI

      https://doi.org/10.1007/s11356-017-0523-z

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 下水,河川水からの医薬品生理活性の検出2018

    • Author(s)
      井原賢, 張 晗, 花本征也,田中宏明
    • Journal Title

      薬学雑誌

      Volume: 38 Pages: 281-287

    • Peer Reviewed
  • [Journal Article] Membrane fouling control and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR2018

    • Author(s)
      J. Park, N.Yamashita, H.Tanaka
    • Journal Title

      Chemosphere

      Volume: 197 Pages: 467-476

    • DOI

      DOI10.1016/j.chemosphere.2018.01.063

    • Peer Reviewed
  • [Journal Article] Assessing the population equivalent and performance of wastewater treatment through the ratios of pharmaceuticals and personal care products present in a river basin: Application to the River Thames basin, UK2017

    • Author(s)
      Nakada, N., Hanamoto, S., Jurgens, MD., Johnson, AC., Bowes, MJ., Tanaka, H.
    • Journal Title

      Science of the Total Environment

      Volume: 575 Pages: 1100-1108

    • DOI

      https://doi.org/10.1016/j.scitotenv.2016.09.180

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Linking changes in antibiotic effluent concentrations to flow, removal and consumption in four different UK sewage treatment plants over four years2017

    • Author(s)
      161.Johnson, AC., Jurgens, MD., Nakada, N., Hanamoto, S., Singer, AC., Tanaka, H.
    • Journal Title

      Environmental Pollution

      Volume: 220 Pages: 919-926

    • DOI

      DOI10.1016/j.envpol.2016.10.077

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Removal characteristics of pharmaceuticals and personal care products: Comparison between membrane bioreactor and various biological treatment processes2017

    • Author(s)
      Park, J., Yamashita, N., Park, C., Shimono, T., Takeuchi, D., Tanaka, H.
    • Journal Title

      Chemosphere

      Volume: 179 Pages: 371-380

    • DOI

      10.1016/j.chemosphere.2017.03.135

    • Peer Reviewed
  • [Journal Article] Removal of pharmaceuticals and personal care products by ammonia oxidizing bacteria acclimated in a membrane bioreactor: Contributions of cometabolism and endogenous respiration2017

    • Author(s)
      Park, J., Yamashita, N., Wu, G., Tanaka, H.
    • Journal Title

      Sci. Total Environ

      Volume: 605-606 Pages: 18-25

    • DOI

      https://doi.org/10.1016/j.scitotenv.2017.06.155

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Detection of physiological activities of pharmaceuticals in river water: Suggestions to prioritization of pharmaceuticals in research involving environmental monitoring and toxicity testing2017

    • Author(s)
      Masaru Ihara, Han Zhang, Seiya Hanamoto, and Hiroaki Tanaka
    • Organizer
      SETAC Europe 26th Annual Meeting
    • Int'l Joint Research / Invited
  • [Presentation] 下水道を取り巻く最近の話題 ー環境規制と再生水の動向ー2017

    • Author(s)
      田中宏明
    • Organizer
      (株)建設技術研究所 大阪本社 意見交換会
    • Invited
  • [Presentation] "The fate of ketoprofen’s photo transformation products in waste water treatment plant"2017

    • Author(s)
      E. Hasegawa, S. Hanamoto, N. Nakada, N. Yamashita, H. Tanaka
    • Organizer
      The 3rd Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Int'l Joint Research
  • [Presentation] Removal characteristics of pharmaceuticals and personal care products in a membrane bioreactor2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      The 3rd Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Int'l Joint Research
  • [Presentation] Fouling control and biodegradability enhancement of pharmaceuticals and personal care products by coagulation-MBR process2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      The 2nd International Conference on Biological Waste as Resource
    • Int'l Joint Research
  • [Presentation] Investigation of main G Protein-Coupled Receptor-acting pharmaceuticals to trigger physiological activities in the wastewater of UK by the in vitro TGFα shedding assay2017

    • Author(s)
      Han ZHANG, Masaru IHARA, Seiya HANAMOTO, Norihide NAKADA, Monika D. JÜRGENS, Andrew C. JOHNSON, Hiroaki TANAKA
    • Organizer
      Micropol & Ecohazard 2017
    • Int'l Joint Research
  • [Presentation] Evaluation of the fate of photoproducts of ketoprofen in urban rivers2017

    • Author(s)
      Hanamoto S, Hasegawa E, Nakada N, Yamashita N, Tanaka H
    • Organizer
      Micropol & Ecohazard 2017
    • Int'l Joint Research
  • [Presentation] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay2017

    • Author(s)
      Masaru Ihara, Mariko O. Ihara, Hiroaki Tanaka
    • Organizer
      SETAC North America 38th Annual Meeting,
    • Int'l Joint Research
  • [Presentation] Prediction and management of emerging chemicals in the water environment2017

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Fumiaki OGAWA, Seiya HANAMOTO, Andrew JOHNSON, Monika JÜRGENS
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Int'l Joint Research
  • [Presentation] Prioritization of main causative β-blockers for physiological activity in UK wastewater2017

    • Author(s)
      Han Zhang, Masaru Ihara, Seiya Hanamoto, Norihide Nakada, Monika D. Jurgens, Andrew C. Johnson, and Hiroaki Tanaka
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Int'l Joint Research
  • [Presentation] Detection of physiological activities of antidepressant pharmaceuticals in wastewater by fluorescence based in vitro assay2017

    • Author(s)
      Masaru Ihara, Mariko O. Ihara, and Hiroaki Tanaka
    • Organizer
      The 19th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Int'l Joint Research
  • [Presentation] Fouling reduction and enhanced removal of pharmaceuticals and personal care products by coagulation-MBR process2017

    • Author(s)
      Park, J., Yamashita, N., Tanaka, H.
    • Organizer
      第54回下水道研究発表会
    • Int'l Joint Research
  • [Presentation] 膜分離活性汚泥法における医薬品類の除去特性とメカニズム解明2017

    • Author(s)
      朴畯遠、山下尚之、田中宏明
    • Organizer
      第20回日本水環境学会シンポジウム
  • [Presentation] In vitroアッセイによる下水中の抗うつ薬様物質の生理活性の検出2017

    • Author(s)
      井原 賢、井原 満理子、加藤 大典、Han Zhang、田中 宏明
    • Organizer
      第20回環境ホルモン学会

URL: 

Published: 2018-12-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi