Gene expression analyses in the mouse digital brain for understanding molecular bases of higher motor disfunction

2017 Fiscal Year Final Research Report

• Project/Area Number: 26280110
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Okamura-Oho Yuko 国立研究開発法人理化学研究所, 光量子工学研究領域, 客員研究員 (60381571)
• Co-Investigator(Kenkyū-buntansha): 横田 秀夫 国立研究開発法人理化学研究所, 光量子工学研究領域, チームリーダー (00261206) ; 太田 聡史 国立研究開発法人理化学研究所, バイオリソースセンター, 専任研究員 (30391890)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 遺伝子発現 / 随意運動 / モーションキャプチャー / ハンチントン病

Outline of Final Research Achievements

More than 85% of genes are expressed in the brain and maintain the structure and execute neural function. We have invented a TT method for profiling gene expression patterns of the whole brain in the three-dimensional coordinate. We have also developed a high-resolution motion capture method and detected subtle changes of walking motion and describe them with parameters of biomechanics. Using these methods, we analyzed a neuronal inherited disease model mouse with abnormal motion. Then, we found parameter changes in motion of abnormal mice and expression-area changes in gene expression of a group of genes in the beginning stages of the disease.

Free Research Field

遺伝学