Understanding the mechanism of how central action of amino acids suppresses hepatic glucose production

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282022
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanazawa University
• Principal Investigator: Inoue Hiroshi 金沢大学, 新学術創成研究機構, 教授 (50397832)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アミノ酸 / 糖産生 / 中枢神経 / 迷走神経 / 肝臓

Outline of Final Research Achievements

We have reported that histidine administration reduced blood glucose levels in mice, by suppressing hepatic glucose production via central histamine action. Although histidine is expected to be a candidate for blood glucose-lowering nutrient, the precise mechanism of how central histidine suppresses hepatic glucose production remains unclear. Here, we found that central action of histidine and histamine decreased hepatic gluconeogenic genes by activating hepatic STAT3 signaling via the vagus nerve. Moreover, we found that the vagus nerve suppressed hepatic IL-6/STAT3 signaling via the α7-nicotinic acetylcholine receptors, and that central insulin action activated hepatic IL-6/STAT3 signaling by suppressing vagal activity.

Free Research Field

食生活学