Mechanism underlying accumulation of dietary life by the novel epigenetic factor Brd4

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282023
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Yamanashi
• Principal Investigator: MOCHIZUKI Kazuki 山梨大学, 総合研究部, 教授 (80423838)
• Co-Investigator(Kenkyū-buntansha): 合田 敏尚 静岡県立大学, 食品栄養科学部, 教授 (70195923)
• Co-Investigator(Renkei-kenkyūsha): HONMA Kazue 静岡県立大学, 食品栄養科学部, 教授 (80724765)
• Research Collaborator: HARIYA Natsuyo 山梨学院大学, 健康栄養学部, 准教授 (80732784)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Brd4 / 生活習慣病 / エピゲノム / 食習慣 / ヒストン修飾

Outline of Final Research Achievements

Life style related diseases are developed by the accumulating information related to various lifestyle habits including dietary habits. In this study, we examined whether life style related diseases are developed by the accumulating dietary habits via the novel epigenetic factor Brd4. We found that Brd4 induceｄ expression of genes related to fat synthesis/accumulation and insulin sensitivity in the liver and adipose tissues. Moreover, Brd4 activation at the healthy state induced obesity and fatty liver, whereas Brd4 repression at the obesity state induced insulin resistance. In addition, we demonstrated in this study that epigenetic biomarkers indicating Brd4 activation would predicts development of life style related diseases.

Free Research Field

分子栄養