Design and synthesis of tumor cell adherent blood compatible materials

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282134
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyushu University
• Principal Investigator: Tanaka Masaru 九州大学, 先導物質化学研究所, 教授 (00322850)
• Research Collaborator: KOBAYASHI SHINGO 九州大学, 先導物質化学研究所, 特任准教授 (70625110) ; HOSHIBA TAKASHI 山形大学, 有機材料システム研究推進本部 (00469769)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 血液適合性 / がん細胞 / 血球細胞 / 水和構造 / 中間水 / 表面

Outline of Final Research Achievements

To decrease the victims of cancer death, the diagnosis of cancer as well as the therapy is important. Circulating tumor cells (CTCs) have received attention for cancer diagnosis and decisions on chemotherapeutic courses. For these purposes, the isolation of CTCs has been expected. In this study, we examined the possibility of capturing CTCs via an adhesion-based method using new poly(2-methoxyethyl acrylate)(PMEA) analogous polymers by controlling the chemical structure, surface properties and intermediate water structure through precision polymer synthesis. Tumor cells can adhere blood compatible PMEA analogous polymers via integrin-dependent and independent mechanism after 30 min and 1 h of incubation, suggesting that these blood compatible polymers possess the ability to capture CTCs from peripheral blood and inform decisions on chemotherapeutic courses.

Free Research Field

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