A novel drug and contrast agent targeting to brain acute ischemic stroke.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26282139
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Masayuki YOkoyama 東京慈恵会医科大学, 医学部, 教授 (20220577)
• Co-Investigator(Renkei-kenkyūsha): SHIRAISHI Koichi 東京慈恵会医科大学, 医学部, 准教授 (40426284)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 急性期脳梗塞 / ＭＲＩ / 造影剤 / 高分子ミセル / 高分子 / 脳保護薬 / ターゲティング

Outline of Final Research Achievements

We aim to establish a proof of concept of novel targeting to acute brain ischemic stroke using macromolecular MRI contrast agents. We successfully prepared two types of contrast agents; polymeric micelle type and non-micelle forming type. Using these agents, we observed their significantly rapid accumulation at the ischemic sites in T1-weighted MR images. Owing to very distinct images with a long-time-lasting character, MRI analyses by the use of macromolecular contrast agents may realize risk prediction of brain hemorrhage induced by the t-PA therapy that is conducted against acute brain ischemic stroke.

Free Research Field

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