2016 Fiscal Year Final Research Report
Immunostimulatory endogenous and exogenous compounds: Synthesis, functional analysis and development of immunomodulatory designed compounds
| Project/Area Number |
26282211
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
井貫 晋輔 慶應義塾大学, 理工学部, 助教 (70736272)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 複合脂質 / 複合糖質 / 免疫調節 / 有機合成 |
|---|
| Outline of Final Research Achievements |
In this study, we first aimed to develop the chemical synthesis of exogenous and endogenous molecules responsible for cooperation between innate immunity and adaptive immunity, and also to analyze the function with using the synthesized compounds. We also aimed to design and produce new-types of molecules that can modulate the immune system. Namely, we first synthesized natural immunomodulatory compounds (especially glyco-conjugates and lipid-conjugates), and then analyzed the structure-activity relationships in the immunomodulatory activities and also the interaction with the recognition protein. Based on these results, the immunomodulatory functions of the natural and designed molecules were successfully shown.
|
| Free Research Field |
生物有機化学
|
