Super resolution Raman microscopy using structured illumination

2016 Fiscal Year Final Research Report

• Project/Area Number: 26286063
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Optical engineering, Photon science
• Research Institution: Osaka University
• Principal Investigator: Fujita Katsumasa 大阪大学, 工学(系)研究科(研究院), 准教授 (80362664)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ラマン顕微鏡 / ラマン分光 / 超解像顕微鏡 / 構造化照明

Outline of Final Research Achievements

A structured illumination Raman microscopy has been developed in order to realize a label-free analytical imaging technique with an improved spatial resolution. The light illumination optics has been newly designed and implemented to a line illumination Raman microscopy. The introduction of structured pattern into the line illumination for Raman scattering detection provided about a twice improvement of the spatial resolution in practical conditions, which corresponds about 1.5-fold improvement from the theoretical limit. The improvement of the spatial resolution has been confirmed by observing polymer nanoparticles ( a mixture of polystyrene and PMMA), carbon nanomaterials (CVD graphene and graphite), biological tissue (fibrous structure of lipid) samples.

Free Research Field

応用物理学