Development of C-H Transformations Using Noncovalent Interactions

2017 Fiscal Year Final Research Report

• Project/Area Number: 26288014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Kyushu University (2015-2017); The University of Tokyo (2014)
• Principal Investigator: Kuninobu Yoichiro 九州大学, 先導物質化学研究所, 教授 (40372685)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: C-H結合変換 / 非共有結合性相互作用 / 水素結合 / Lewis酸－塩基相互作用 / ボリル化 / シリル化 / メタ位 / オルト位

Outline of Final Research Achievements

I conducted researches aimed at developing high regioselective carbon-hydrogen (C-H) bond transformations using noncovalent interactions, such as a Lewis acid-base interaction or a hydrogen bonding. As a result, I developed meta-selective C(sp2)-H bond transformation utilizing the hydrogen bonding and ortho-selective C(sp2)-H bond transformation using the Lewis acid-base interaction. These reactions are the first examples that control the regioselectivity of C-H bond transformations by hydrogen bonding or Lewis acid-base interaction between a ligand of the catalyst and a substrate. In addition, I could achieve to creat a new regiocontrol method in C-H bond transformations.

Free Research Field

有機合成化学、有機金属化学、有機材料化学