Synthetic Study of Biologically Active Natural Products Based on the Novel Chiral Pool Approach

2017 Fiscal Year Final Research Report

• Project/Area Number: 26288018
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Keio University
• Principal Investigator: CHIDA Noritaka 慶應義塾大学, 理工学部(矢上), 教授 (50197612)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 天然物合成 / キラルプール法 / タキソール / ネオステニン / カイトセファリン

Outline of Final Research Achievements

The chiral pool approach is a highly effective and reliable method for the synthesis of biologically active natural products in optically pure form. In this project, synthetic studies toward taxol (diterpenoids possessing anticancer activity), neostenine (alkaloid with antitussive activity), and kaitocephalin (amino acid with antagonistic activity of glutamate receptor), based on the chiral pool approach utilizing carbohydrate as starting material, were carried out. The successful syntheses of these natural products revealed the effectiveness of the chiral pool methodology and brought about the progress of the methodology.

Free Research Field

有機合成化学