N-heterocyclic carbene-modified gold nanoparticles for biosensing

2017 Fiscal Year Final Research Report

• Project/Area Number: 26288023
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Nagoya University
• Principal Investigator: Crudden Cathleen 名古屋大学, トランスフォーマティブ生命分子研究所, 客員教授 (10721029)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIYAMA Tetsuya 名古屋大学, トランスフォーマティブ生命分子研究所, 教授 (00313205) ; NAMBO Masakazu 名古屋大学, トランスフォーマティブ生命分子研究所, 特任講師 (10705528)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ナノ材料 / 金ナノ粒子 / N-ヘテロサイクリックカルベン / バイオイメージング / 安定性 / 二座配位子

Outline of Final Research Achievements

The goal of this grant was to prepare and test stable gold nanoparticles for potential biosensing applications. We have prepared new gold nanoparticles that were protected by carboxylate-functionalized N-heterocyclic carbenes (NHCs) to be water-souble. The resulting gold particles were stable in the presence of electrolytes and gave photoacoustic signals. In addition, we successfully increased stability of gold nanoparticles against thiols by employing bidentate NHC ligands functionalized with long alkyl chains.

Free Research Field

有機金属化学