2016 Fiscal Year Final Research Report
Molecular Chemistry on Cell Membrane Using Functional Nucleic Acid
| Project/Area Number |
26288081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SANDO SHINSUKE 東京大学, 工学(系)研究科(研究院), 教授 (20346084)
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| Co-Investigator(Kenkyū-buntansha) |
岡本 晃充 東京大学, 先端科学技術研究センター, 教授 (60314233)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 細胞膜 / センサー / 生体分子 |
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| Outline of Final Research Achievements |
Cell membrane is an essential component of cells and there has been a continuing demand on method to analyze molecular functions on the cell membrane. In this research, we tried to design fluorescent aptamer sensors with a high performance and developed BODIPY dye-labeled fluorescent aptamer sensors that emit an enhanced fluorescence upon interaction with target biomolecule (adenine compound or interferon gamma). In addition, it was demonstrated that these fluorescence aptamer sensors work on cell membrane and can be used for a fluorescent molecular imaging.
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| Free Research Field |
生体機能関連化学
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