2017 Fiscal Year Final Research Report
Chemical biology for elucidation of molecular basis of telomeric RNA G-quadruplex structure
| Project/Area Number |
26288083
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | University of Miyazaki |
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Principal Investigator |
XU YAN 宮崎大学, 医学部, 教授 (40506763)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | テロメアRNA高次構造 / ケミカルバイオロジー / 生体分子 / 核酸 / 有機化学 |
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| Outline of Final Research Achievements |
(1) In 19F NMR analysis of the structure of human telomeric RNA in living cells and in what manner interacts with proteins and ligand molecules (Nucleic Acids Res. 45, 5501, 2017; Nature Protocols 13, 652, 2018.) (ChemistrySelect, 2, 4170, 2017; JACS. 139, 7533, 2017; Molecules 23, 237, 2018). (2) We have discovered the antiparallel RNA quadruplex structure which was thought not to exist until now (Sci. Rep. 7, 6695, 2017; Chem. Commun. 54, 3944, 2018.). (3) We succeeded in developing multifunctional guanine derivatives for detecting G-quadruplex structure (Analyst 142, 4083, 2017; ACS Omega 2, 8843, 2017). (4) We succeeded in analyzing DNA-RNA hybrid quadruplex structure in the cell and detection of telomere DNA by utilizing the click reaction (Bioorg. Med. Chem. 135, 44191, 2014; J. Nat Sci. 2: e 237, 2016; Sci. Rep. 6, 33217, 2016.).
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| Free Research Field |
生体関連化学
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