Hierarchical analyses of manifestation mechanism of biocompatibility

2016 Fiscal Year Final Research Report

• Project/Area Number: 26288100
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: University of Toyama
• Principal Investigator: Kitano Hiromi 富山大学, 大学院理工学研究部(工学), シニアアドバイザー (40115829)
• Co-Investigator(Renkei-kenkyūsha): NAKAJI Tadashi (HIRABAYASHI Tadashi) 富山大学, 大学院理工学研究部(工学), 准教授 (10543217) ; GEMMEI Makoto (IDE Makoto) 富山大学, 大学院理工学研究部(工学), 准教授 (70334711) ; NOGUCHI Hidenori 独立行政法人物質・材料研究機構, エネルギー・環境材料研究拠点, 主席研究員 (60374188)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 水分子の配向 / 電荷中和 / 高分子イオンコンプレックス / 双性イオン型高分子 / 両性高分子 / 和周波発生法 / 蛍光相関分光法

Outline of Final Research Achievements

Using sum frequency generation (SFG) spectroscopy, it was found that water molecules in the vicinity of zwitterionic and charge-neutralized polymer materials are not largely oriented in comparison with those in the vicinity of lopsidedly charged polymer materials. Taking account of excellent anti-coagulant and biocompatible properties of the zwitterionic and charge-neutralized polymer materials, the absence or drastic reduction of the orientation of vicinal water molecules is suggested to be very essential for the bio-inertness of polymer materials. Furthermore, using the temperature-variable infrared spectroscopy and molecular dynamics, it was found that the so-called recrystallization phenomena observed in the water-saturated anti-coagulant polymer materials such as poly(2-methoxyethyl acrylate) (PMEA) are not dominated by the reorientation but the diffusion process of water molecules within the polymer materials.

Free Research Field

高分子界面科学