Development of Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3

2016 Fiscal Year Final Research Report

• Project/Area Number: 26289010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Materials/Mechanics of materials
• Research Institution: Doshisha University
• Principal Investigator: NAKAMACHI EIJI 同志社大学, 生命医科学部, 教授 (60099893)
• Co-Investigator(Kenkyū-buntansha): 森田 有亮 同志社大学, 生命医科学部, 教授 (80368141) ; 萩原 明郎 同志社大学, 生命医科学部, 教授 (90198648)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生体適合材料 / 再生用デバイス / 電磁場刺激 / 力学刺激 / 神経細胞PC12 / 神経軸索伸展 / コンピュータシミュレーション

Outline of Final Research Achievements

We developed a Mechanical Electro-Magneto Nerve Regeneration Device with Biocompatible Piezoelectric Material MgSiO3, as demonstrated below: (1) Cellular Automaton Simulation code. (2) Bio-MEMS device for activate the axonal extension of nerve cell PC12 to study the influence of cell interval and zenith corner angle. (3) Multi-layer diaphragm using the biocompatible piezoelectric material MgSiO3 to generate mechanical static electro magneto field. (4) AC magneto field stimulation device for PC12 axonal extension acceleration. (5) Electro magneto mechanical stimulation device in the extra-cellular environment to activate PC12 cell and axonal extension. We confirmed that increases of 25.2% in case of mechanical stimulation, 37.4% in the uniform magneto field stimulation and 70.0% in the mechanical electro magneto hybrid stimulation.

Free Research Field

機械材料・材料力学