Elucidation of the posture control disability in cerebellar ataxia from the model-based evaluation of patients and rodents

2016 Fiscal Year Final Research Report

• Project/Area Number: 26289063
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Intelligent mechanics/Mechanical systems
• Research Institution: The University of Electro-Communications
• Principal Investigator: Funato Tetsuro 電気通信大学, 情報理工学(系)研究科, 助教 (40512869)
• Co-Investigator(Kenkyū-buntansha): 柳原 大 東京大学, 総合文化研究科, 准教授 (90252725) ; 石川 欽也 東京医科歯科大学, 医学部附属病院, 教授 (30313240) ; 青井 伸也 京都大学, 工学(系)研究科(研究院), 講師 (60432366)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 姿勢制御 / 小脳疾患 / 力学モデル / 動物モデル

Outline of Final Research Achievements

In order to elucidate the mechanism that the cerebellar ataxia yielded the posture control disability, this research constructed an evaluation method of posture control system from measured biological data and dynamical model. As a result, 1: dynamical model with variable postural state and its evaluation method, 2: noble standing experiment of rats with bipedal standing were constructed, and through these two methods, the posture disability due to cerebellar ataxia could be evaluated as the change in the control system. By evaluating the standing motion of rats with lesion in inferior olivary nuclei and a patient with cerebellar ataxia, change in the posture control system such that the decreased control torque of rats and decreased integral control of the patient were numerically shown.

Free Research Field

制御工学・バイオメカニクス