Skeletal muscle tissue engineering by magnetic force-based nanotechnology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26289315
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Kyushu University
• Principal Investigator: Ito Akira 九州大学, 工学(系)研究科(研究院), 准教授 (60345915)
• Co-Investigator(Kenkyū-buntansha): 清水 一憲 名古屋大学, 工学(系)研究科(研究院), 准教授 (70402500)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ティッシュエンジニアリング / 骨格筋 / 再生医療 / iPS細胞 / 磁性ナノ粒子 / 薬剤スクリーニング / マイクロデバイス / 筋ジストロフィ

Outline of Final Research Achievements

In this study, we have developed a novel technology of skeletal muscle tissue engineering, designated "magnetic force-based tissue engineering (Mag-TE)", for regenerative medicine and drug discovery. The most important characteristic of skeletal muscle is force generation. We constructed three dimensional skeletal muscle tissues by Mag-TE technique and showed that the tissue-engineered skeletal muscles contracted and generated force upon electrical pulse stimulation. In the present study, 1) we explored a method of myogenic differentiation of human iPS cells; 2) we demonstrated that the contractility data is indispensable for evaluation of in vitro tissue-engineered skeletal muscle grafts; 3) we developed micro devices for high throughput screening of muscular disease drugs.

Free Research Field

生物化学工学