Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26290019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Saito Takashi 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (90360552)
• Research Collaborator: MATSUBA Yukio 理化学研究所, 神経蛋白制御研究チーム, テクニカルスタッフ ; Mihira Naomi 理化学研究所, 神経蛋白制御研究チーム, テクニカルスタッフ
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳老化 / アルツハイマー病 / モデルマウス

Outline of Final Research Achievements

To elucidate molecular mechanisms for pathogenesis of Alzheimer’s disease, we investigated a role of intracellular and extracellular quality control system in next generation AD mouse models, Amyloid precursor protein (APP) knockin (KI) mice, which we developed. The results taken by using existed AD mouse models which were APP overexpressing model in almost case could not be reproduced by using APP KI mice due to artifacts of APP overexpressing mouse models. Thereby, APP KI mouse models would be new world standard model for AD research community and be useful for elucidation of molecular mechanisms under pathogenesis of AD.

Free Research Field

神経科学