Regulation of metabolism by RB tumor suppressor gene

2016 Fiscal Year Final Research Report

• Project/Area Number: 26290037
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Takahashi Chiaki 金沢大学, がん進展制御研究所, 教授 (50283619)
• Co-Investigator(Renkei-kenkyūsha): Hayashi Naoyuki 金沢大学, がん進展制御研究所, 助教 (50253456) ; Kitajima Syunsuke 金沢大学, がん進展制御研究所, 特任助教 (90566465) ; Shamma Awad 金沢大学, がん進展制御研究所, 助教 (50402839) ; Kohno Susumu 金沢大学, がん進展制御研究所, 研究員 (30625463) ; Sasaki Nobunari 金沢大学, がん進展制御研究所, 研究員 (40415170)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がん代謝 / RB / 解糖系 / 脂質代謝

Outline of Final Research Achievements

We found that PGAM1 and 2 mediate function of RB tumor suppressor to regulate glycolysis. We also clarified how RB controls transcription of these genes. A further study demonstrated that PGAMs mediate RB function to control differentiation. On the other hand, we investigated the clinical significance of the RB function to control cholesterol synthesis. RB loss via increasing cholesterol synthesis recruits androgen receptor (AR) to nucleus and reduces ROS. These phenomenons were antagonized addition of statins, Lastly, we performed lipidomics analysis of RB-inactivated cells, which indicated that RB status gives significant impact on the quantitative and qualitative status of fatty acids,

Free Research Field

腫瘍分子生物学