Comparison of the effect to cancer metastasis between photon and particle beam

2016 Fiscal Year Final Research Report

• Project/Area Number: 26290055
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Osaka University
• Principal Investigator: koizumi masahiko 大阪大学, 医学(系)研究科(研究院), 教授 (90186594)
• Co-Investigator(Kenkyū-buntansha): 松浦 成昭 大阪大学, 医学(系)研究科(研究院), 教授 (70190402) ; 出水 祐介 神戸大学, 医学(系)研究科(研究院), 准教授 (50452496) ; 不破 信和 横浜市立大学, 医学(系)研究科(研究院), その他 (50156981)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: がん転移 / 炭素イオン線 / 陽子線 / 遊走能 / 浸潤能 / SUN / CD44

Outline of Final Research Achievements

The cell migration and invasion capability were evaluated after X, carbon ion or proton beam irradiation on each cancer cell lines (lung, breast, pancreatic and prostate cancer). Low dose X-irradiation enhanced the cell migration and invasion. Carbon ion beam inhibited the capability dose dependently. Proton beam had unique character. Low dose proton irradiation enhanced the cell migration and invasion, on the other hand, high dose inhibited the metastatic potentials. The expression of nuclear membrane protein SUN was increased by X-irradiation. Carbon ion beam didn't have ability that increased the expression of SUN. We have demonstrated that particle therapy has inhibited the cancer metastatic potentials compared with photon therapy.

Free Research Field

放射線治療学