Regulation mechanisms for tissue-specific post-transcriptional pre-mRNA processing.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26291003
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Molecular biology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUROYANAGI Hidehito 東京医科歯科大学, 難治疾患研究所, 准教授 (30323702)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 遺伝子発現 / 新生RNA / 線虫 / 組織特異性 / 転写後プロセシング / mRNA / ChIP-seq / 代謝標識

Outline of Final Research Achievements

We revealed binding regions of LST-3 genome wide and mechanisms for splicing regulation by LST-3. We have analyzed tissue-specific alternative splicing patterns of the lev-11 gene, encoding tropomyosin, in C. elegans. We published a review article on alternative splicing regulation in C. elegans. We tried TU-tagging to label nascent RNAs in tissue-specific manners in living worms.

Free Research Field

分子生物学