Identification of novel pathways consist of DGK isozymes using new analyzing methods and regulation of their functions

2016 Fiscal Year Final Research Report

• Project/Area Number: 26291017
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Chiba University
• Principal Investigator: Sakane Fumio 千葉大学, 理学(系)研究科(研究院), 教授 (10183815)
• Co-Investigator(Renkei-kenkyūsha): SAKAI HIROMICHI 島根大学, 総合科学研究支援センター, 助教 (00375255)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 細胞情報伝達機構 / 脂質 / ジアシルグリセロール / リン酸化 / 活性制御

Outline of Final Research Achievements

Diacylglycerol kinase (DGK) contains ten isozymes. We have recently found that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways and are involved in pathogenesis of refractory diseases. Thus, we planned to find (1) novel pathways consist of DGK isozymes and to reveal their patho-physiological functions. We obtained interesting results concerning new metabolic pathways that are composed of DGKα, δ, η and ζ, and their patho-physiological functions (e.g., cancer, immunity, bipolar disorder, obsessive-compulsive disorder, and Parkinson’s disease).

Free Research Field

生化学