Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function

2016 Fiscal Year Final Research Report

• Project/Area Number: 26291022
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kobe University
• Principal Investigator: Matozaki Takashi 神戸大学, 医学(系)研究科(研究院), 教授 (80252782)
• Co-Investigator(Renkei-kenkyūsha): OHNISHI Hiroshi 群馬大学, 大学院保健学研究科, 教授 (70334125) ; MURATA Yoji 神戸大学, 大学院医学研究科, 准教授 (60400735) ; SAITO Yasuyuki 神戸大学, 大学院医学研究科, 講師 (40508842) ; KOTANI Takenori 神戸大学, 大学院医学研究科, 助教 (40455960)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: シグナル伝達 / 生体分子 / 脳・神経 / 免疫学 / 癌

Outline of Final Research Achievements

We have here investigated the molecular basis of the CD47-SIRPα signaling system in the regulation of physiological function in the central nervous system (CNS) as well as in the immune system. In the CNS, we have shown that the protein tyrosine phosphatase Shp-2, which is a downstream molecule of SIRPα, regulates synaptic functions and thereby modulates learning and locomotor activity. In the immune system, we have shown that SIRPα is essential for the maintenance of dendritic cell homeostasis in the secondary lymphoid organs and skin. Furthermore, we have found that anti-SIRPα antibodies appear to be a potential new tool for cancer immunotherapy.

Free Research Field

生化学、分子生物学