2017 Fiscal Year Final Research Report
Basic principles of voltage sensing
| Project/Area Number |
26291030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | イオンチャネル |
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| Outline of Final Research Achievements |
In this study, we tried to clarify voltage-sensing mechanism of the voltage-gated channels which generate and regulate bioelectronic signals as represented by the heartbeat and brain functions. We focused on the voltage-gated H+ channel consisting of a minimum voltage-sensor unit, and analyzed the voltage-sensor movement by membrane voltage and the structural rearrangement toward the channel opening. We demonstrated the molecular basis of the voltage-sensing mechanism.
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| Free Research Field |
生理学
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