Structural basis for cytoplasmic dynein regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 26291034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biophysics
• Research Institution: Osaka University (2015-2017); Hosei University (2014)
• Principal Investigator: Kon Takahide 大阪大学, 大学院理学研究科, 教授 (30332620)
• Co-Investigator(Renkei-kenkyūsha): KURISU Genji 大阪大学, 蛋白質研究所, 教授 (90294131) ; FURUTA Kenya 独立行政法人情報通信研究機構, 未来ICT研究所, 主任研究員 (40571831)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 分子モーター / 構造生物学 / ナノマシン / 酵素反応

Outline of Final Research Achievements

Dynein is a huge microtubule-based motor complex that powers a wide variety of biological processes within eukaryotic cells, including cell division, cell migration, and the intracellular trafficking. However, the regulatory mechanism of dynein, which is critical for exerting these diverse cellular functions, still remains unclear. Here, we have performed electron microscopic analysis of dynein inactivated complex. This study provides a structural basis for understanding the mechanism underlying dynein-based motility.

Free Research Field

生物物理学・生化学・構造生物学